T
Takeo Taguchi
Researcher at University of Tokyo
Publications - 237
Citations - 3069
Takeo Taguchi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Allylic rearrangement & Trifluoromethyl. The author has an hindex of 29, co-authored 237 publications receiving 2984 citations. Previous affiliations of Takeo Taguchi include Tokushima Bunri University.
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Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action.
Hiroyuki Nakano,Tsutomu Inoue,Nobuhide Kawasaki,Hideki Miyataka,Hitoshi Matsumoto,Takeo Taguchi,Naoki Inagaki,Hiroichi Nagai,Toshio Satoh +8 more
TL;DR: In this paper, a number of new benzimidazole derivatives were synthesized and their pharmacological activities were examined, including a good suppressive action on histamine release from rat peritoneal mast cells produced by antigen-antibody reaction, an antagonistic action on guinea pig ileum contraction caused by histamine, an inhibitory action on 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and a preventive action on NADPH dependent lipid peroxidation induced by Fe3+-ADP
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Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides
Takeo Taguchi,Osamu Kitagawa,Tsutomu Morikawa,Tohru Nishiwaki,Hideya Uehara,Hatsumi Endo,Yoshiro Kobayashi +6 more
TL;DR: In this article, the formation of CC bond through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield.
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Synthesis of 3,3-difluoro-2-azetidinones and 2,3-dideoxy-2,2-difluoro-3-amino-sugars through the reformatsky reaction of difluoroacetate with imine
Takeo Taguchi,Osamu Kitagawa,Yoshimitsu Suda,Shinji Ohkawa,Akihiro Hashimoto,Yohichi Iitaka,Yoshiro Kobayashi +6 more
TL;DR: The reformatsky reaction of iodo- or bromodifluoroacetate with imine gave the corresponding 3,3-difluoroketene silyl acetal derivative.
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Synthesis of optically active cis- and trans-1,2-disubstituted cyclopropane derivatives by the Simmons-Smith reaction of allyl alcohol derivatives derived from (R)-2,3-O-isopropylideneglyceraldehyde
TL;DR: The Simmons-Smith reactions of Z- and E-allyl alcohol derivatives derived from (R)-2,3-O-isopropylideneglyceraldehyde (6) were used for the synthesis of optically active cis- and trans-1,2-disubstituted cyclopropane derivatives.
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An enantioselective Michael addition of soft nucleophiles to prochiral enone catalyzed by (2-pyrrolidyl)alkyl ammonium hydroxide
Akihiro Kawara,Takeo Taguchi +1 more
TL;DR: In this paper, the soft nucleophiles were added to enones with moderate to high enantiomeric excess through ion-pair rather than steric control to catalyze the asymmetric Michael addition.