Takeya Tsutsumi

TL;DR: It is indicated that the HCV core protein has a chief role in the development of HCC, and that these transgenic mice provide good animal models for determining the molecular events in hepatocarcinogenesis with HCV infection.

TL;DR: The ability of insulin to lower the plasma glucose level in the HCV transgenic mice was impaired, as observed in chronic hepatitis C patients, providing a direct experimental evidence for the contribution of HCV in the development of insulin resistance in human HCV infection, which finally leads to theDevelopment of type 2 diabetes.

TL;DR: The HCV core protein alters the oxidant/antioxidant state in the liver in the absence of inflammation and may thereby contribute to or facilitate, at least in part, the development of HCC in HCV infection.

TL;DR: The data suggest that the replication of HBV may persist in some organs, most likely in the liver or peripheral blood cells, for a long period after recovery from acute hepatitis B, and the data indicate the possible transmission ofHBV from organ transplantation donors who exhibit serological markers of past infection only.

TL;DR: Results suggest that modulation of RXRα‐controlled gene expression via interaction with the core protein contributes to the pathogenesis of HCV infection.