K
Kotaro Ishibashi
Publications - 5
Citations - 2600
Kotaro Ishibashi is an academic researcher. The author has contributed to research in topics: Hepatitis C virus & Steatosis. The author has an hindex of 5, co-authored 5 publications receiving 2547 citations.
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Journal ArticleDOI
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice.
Kyoji Moriya,Hajime Fujie,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Takeya Tsutsumi,Kotaro Ishibashi,Yoshiharu Matsuura,Satoshi Kimura,Tatsuo Miyamura,Kazuhiko Koike +9 more
TL;DR: It is indicated that the HCV core protein has a chief role in the development of HCC, and that these transgenic mice provide good animal models for determining the molecular events in hepatocarcinogenesis with HCV infection.
Journal ArticleDOI
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.
Kyoji Moriya,Hiroshi Yotsuyanagi,Yoshizumi Shintani,Hajime Fujie,Kotaro Ishibashi,Yoshiharu Matsuura,Tatsuo Miyamura,Kazuhiko Koike +7 more
TL;DR: It is indicated that the HCV core protein plays a direct role in the development of hepatic steatosis, which characterizes hepatitis C, and this transgenic mouse system would be a good animal model for the study of pathogenesis in human HCV infection.
Journal Article
Oxidative Stress in the Absence of Inflammation in a Mouse Model for Hepatitis C Virus-associated Hepatocarcinogenesis
Kyoji Moriya,Kiyotaka Nakagawa,Tomofumi Santa,Yoshizumi Shintani,Hajime Fujie,Hideyuki Miyoshi,Takeya Tsutsumi,Teruo Miyazawa,Kotaro Ishibashi,Toshiharu Horie,Kazuhiro Imai,Toru Todoroki,Satoshi Kimura,Kazuhiko Koike +13 more
TL;DR: The HCV core protein alters the oxidant/antioxidant state in the liver in the absence of inflammation and may thereby contribute to or facilitate, at least in part, the development of HCC in HCV infection.
Journal ArticleDOI
Sialadenitis histologically resembling Sjögren syndrome in mice transgenic for hepatitis C virus envelope genes
Kazuhiko Koike,Kyoji Moriya,Kotaro Ishibashi,Hiroshi Yotsuyanagi,Yoshizumi Shintani,Hajime Fujie,Kiyoshi Kurokawa,Yoshiharu Matsuura,Tatsuo Miyamura +8 more
TL;DR: Observations suggest that HCV might be involved in the pathogenesis of sialadenitis in humans and that this transgenic mouse system would be a good animal model for the study of HCV infection.
Journal ArticleDOI
Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans.
Kyoji Moriya,Toru Todoroki,Takeya Tsutsumi,Takeya Tsutsumi,Hajime Fujie,Yoshizumi Shintani,Hideyuki Miyoshi,Kotaro Ishibashi,Tadatoshi Takayama,Masatoshi Makuuchi,Kiyoaki Watanabe,Tatsuo Miyamura,Satoshi Kimura,Kazuhiko Koike +13 more
TL;DR: The results suggest that HCV may affect a specific pathway in the lipid metabolism and cause steatosis in the liver.