Tamara Vasiljevik

TL;DR: The present study indicates that further work examining the physiological effects of synthetic cannabinoid metabolism is warranted, and suggests that a complex mix of metabolically produced CB1R ligands may contribute to the adverse effect profile of JWH-073-containing products.

TL;DR: Data demonstrate that repeated ∆(9)-THC, JWH-018 andJWH-073 can induce long-lasting tolerance to some in vivo effects, which is likely mediated by region-specific downregulation and desensitization of CB1Rs.

TL;DR: It is shown that systematic modification of an aminoalkylindole scaffold identified two new compounds with dual CB1R antagonist/CB2R agonist activity with potential for use as treatments of alcohol abuse.

TL;DR: Findings suggest that different aromatic groups appended directly to the decalin core may be well tolerated by KOP receptors, and may generate further ligands with affinity and activity at kappa opioid receptors.

TL;DR: Experimental evidence is presented that sustained treatment with a non-selective cannabinoid agonist or selective CB2 receptor agonists upregulate 5-HT(2A) receptors in a neuronal cell line to provide a molecular mechanism by which activation of cannabinoid receptors might be relevant to some cognitive and mood disorders in humans.