T
Tamás Németh
Researcher at Semmelweis University
Publications - 23
Citations - 1189
Tamás Németh is an academic researcher from Semmelweis University. The author has contributed to research in topics: Syk & Inflammation. The author has an hindex of 14, co-authored 23 publications receiving 862 citations. Previous affiliations of Tamás Németh include Hungarian Academy of Sciences.
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Journal ArticleDOI
Neutrophils as emerging therapeutic targets
TL;DR: An overview of the biological and pathological functions of neutrophils is provided, assessing emerging strategies to therapeutically target neutrophil function and agents currently under investigation.
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The role of neutrophils in autoimmune diseases.
Tamás Németh,Attila Mócsai +1 more
TL;DR: In this paper, the role of neutrophils in the development of systemic lupus erythematosus and rheumatoid arthritis is discussed. And the authors also discuss neutrophil cell surface receptors (e.g. integrins, Fc-receptors or chemokine receptors) and intracellular signal transduction pathways (i.e. Syk and other tyrosine kinases) in pathogenesis of autoimmune inflammation.
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The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice
Cecília Csölle,Rómeó D. Andó,Ágnes Kittel,Flóra Gölöncsér,Mária Baranyi,Krisztina Soproni,Dóra Zelena,József Haller,Tamás Németh,Attila Mócsai,Beáta Sperlágh +10 more
TL;DR: Evidence is presented that the absence of P2rx7s on non-haematopoietic cells leads to a mood-stabilizing phenotype in several behavioural models and a therapeutic potential of P1X7 antagonists for the treatment of mood disorders is suggested.
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Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
TL;DR: The various tyrosine kinase signaling pathways and their role in various autoimmune and inflammatory skin diseases are reviewed and special emphasis will be placed on identification of potential therapeutic targets.
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Dasatinib inhibits proinflammatory functions of mature human neutrophils.
TL;DR: The results suggest that dasatinib treatment may affect the proinflammatory functions of mature neutrophils and raise the possibility that dAsatinib-related compounds may provide clinical benefit in neutrophil-mediated inflammatory diseases.