T
Tamer M. Ibrahim
Researcher at Kafrelsheikh University
Publications - 44
Citations - 790
Tamer M. Ibrahim is an academic researcher from Kafrelsheikh University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 11, co-authored 34 publications receiving 450 citations. Previous affiliations of Tamer M. Ibrahim include British University in Egypt & University of Tübingen.
Papers
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Journal ArticleDOI
New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations
Adnan A. Bekhit,Eskedar Lodebo,Ariaya Hymete,Hanan M. Ragab,Salma A. Bekhit,Kikuko Amagase,Afnan Batubara,Mohammed A.S. Abourehab,Alaa El-Din A. Bekhit,Tamer M. Ibrahim +9 more
TL;DR: In vivo evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium berghei infected mice obtained promising inhibitory activities of the parasite multiplication, indicating an antifolate mechanism via targeting leishmanial DHFR and PTR1.
Journal ArticleDOI
Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer.
Laila Akl,Amer Ali Abd El-Hafeez,Tamer M. Ibrahim,Rofaida Abdelmoaty Salem,Hala Mohamed M. Marzouk,Ramadan A. El-Domany,Pradipta Ghosh,Wagdy M. Eldehna,Sahar M. Abou-Seri +8 more
TL;DR: In this article , a series of 1-piperazinyl-4-benzylphthalazine derivatives (8a-g, 10a-i and 12a-d) were identified as promising anticancer agents with CDK1 inhibitory activity.
Proceedings ArticleDOI
In-Silico Comparative Analysis of Egyptian SARS CoV-2 with Other Populations: a Phylogeny and Mutation Analysis
Lamis Sharawy,Maha Am Tantawy,Yara Ahmed,Ahmed Abdel-Monem Taha,Omar Soliman,Tamer M. Ibrahim,Mohamed El-Hadidi +6 more
TL;DR: Investigation of how the viral genetic code mutated locally and what variations is the Egyptian population most susceptible to in comparison with different strains isolated from Asia, Europe and other countries in Africa finds that the African mutation pattern is a partial subset of the complete European mutation pattern.
Journal ArticleDOI
Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities
Mostafa M.M. El-Miligy,Marwa Abdelaziz,Salwa M. Fahmy,Tamer M. Ibrahim,Marwa M. Abu-Serie,Mona Mahran,Aly A. Hazzaa +6 more
TL;DR: In this article , quinoline-pyridine hybrids were designed and synthesized as PIM-1/2 kinase inhibitors for low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia.
Journal ArticleDOI
Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity
Souraya Domiati,Khaled H. Abd El Galil,Mohammed A.S. Abourehab,Tamer M. Ibrahim,Hanan M. Ragab +4 more
TL;DR: In this paper , a structure-guided modeling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory effect with a good safety profile.