T
Tamer M. Ibrahim
Researcher at Kafrelsheikh University
Publications - 44
Citations - 790
Tamer M. Ibrahim is an academic researcher from Kafrelsheikh University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 11, co-authored 34 publications receiving 450 citations. Previous affiliations of Tamer M. Ibrahim include British University in Egypt & University of Tübingen.
Papers
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Journal ArticleDOI
Synthesis, molecular modeling and biological screening of some pyrazole derivatives as antileishmanial agents
Adnan A. Bekhit,Adnan A. Bekhit,Manal N. S. Saudi,Ahmed Mm Hassan,Salwa M. Fahmy,Tamer M. Ibrahim,Doaa A. Ghareeb,Aya M. El-Seidy,Sayed Mahmood Alqallaf,Huda J Habib,Alaa El-Din A. Bekhit +10 more
TL;DR: This study offers promising entities for antileishmanial activity and drug-likeness and toxicity predictions showed acceptable profiles for most of the compounds, which were validated by experimental toxicity studies.
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Synthesis, biological evaluation and modeling of hybrids from tetrahydro-1H-pyrazolo[3,4-b]quinolines as dual cholinestrase and COX-2 inhibitors.
Mohamed Mroueh,Wissam H. Faour,Wassim N. Shebaby,Costantine F. Daher,Tamer M. Ibrahim,Hanan M. Ragab +5 more
TL;DR: In silico docking experiments of the active compounds against hAChE rationalized the observed in vitro AChE inhibitory activity, providing an extension of the chemical space of tetrahydro-1H-pyrazolo[3,4-b]quinoline chemotype for the anticholinestrase and anti-inflammatory activity.
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pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening.
TL;DR: pROC-Chemotype is developed, an automated protocol that matches and visualizes ligand chemotype information together with potency classes in the pROC profiles obtained by docking, which can be utilized to identify and highlight chemotype-specific behavior, e.g., in dataset preparation.
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Facilitating SARS CoV-2 RNA-Dependent RNA polymerase (RdRp) drug discovery by the aid of HCV NS5B palm subdomain binders: In silico approaches and benchmarking.
Laila K. Elghoneimy,Muhammad I. Ismail,Frank M. Boeckler,Hassan M.E. Azzazy,Tamer M. Ibrahim +4 more
TL;DR: In this paper, the authors used the reported small-molecule binders to the palm subdomain of HCV NS5B (genotype 1b) to generate a high-quality DEKOIS 20 benchmark set and conducted a benchmarking analysis against HCVNS5B.
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Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors.
Marwa M. Shaaban,Hanan M. Ragab,Kenichi Akaji,Ross P. McGeary,Alaa-Eldin A. Bekhit,Waleed M. Hussein,Julia L. Kurz,Bassma H. Elwakil,Salma A. Bekhit,Tamer M. Ibrahim,Mona A. Mahran,Adnan A. Bekhit,Adnan A. Bekhit +12 more
TL;DR: In vivo toxicity testing exhibited that the most active compound was non-toxic and well tolerated by the experimental animals orally up to 350 mg/kg and parenterally and the docking experiments on NDM-1 and IMP-1 rationalized the observed in vitro MBLs inhibition activity.