T
Tamimount Mohammadi
Researcher at Utrecht University
Publications - 9
Citations - 688
Tamimount Mohammadi is an academic researcher from Utrecht University. The author has contributed to research in topics: Lipid II & Integral membrane protein. The author has an hindex of 6, co-authored 9 publications receiving 649 citations. Previous affiliations of Tamimount Mohammadi include University of Amsterdam.
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Journal ArticleDOI
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.
Tamimount Mohammadi,Vincent van Dam,Robert Sijbrandi,Thierry Vernet,André Zapun,Ahmed Bouhss,Marlies Diepeveen-de Bruin,Martine Nguyen-Distèche,Ben de Kruijff,Eefjan Breukink +9 more
TL;DR: This study provides the first biochemical evidence for the involvement of an essential protein in the transport of lipid‐linked cell wall precursors across biogenic membranes.
Journal ArticleDOI
The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli
Tamimount Mohammadi,Aneta Karczmarek,Muriel Crouvoisier,Ahmed Bouhss,Dominique Mengin-Lecreulx,Tanneke den Blaauwen +5 more
TL;DR: It is postulated that the involvement of MurG in the peptidoglycan synthesis concurs with two complexes, one implicated in cell elongation and the other in division, and a model representing the first complex is proposed.
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The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro
Tamimount Mohammadi,Ginette E. J. Ploeger,Jolanda Verheul,Anouskha D. Comvalius,Ariadna Martos,Carlos Alfonso,Jan van Marle,Germán Rivas,Tanneke den Blaauwen +8 more
TL;DR: In this article, the FtsZ−ZapA interaction at the physiological pH of 7.5 instead of pH 6.5 was studied under conditions that stimulate protofilament formation (5 mM MgCl2) and under conditions both stimulating and stabilizing the formation.
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Specificity of the transport of lipid II by FtsW in Escherichia coli
Tamimount Mohammadi,Robert Sijbrandi,Mandy Lutters,Jolanda Verheul,Nathaniel I. Martin,Tanneke den Blaauwen,Ben de Kruijff,Eefjan Breukink +7 more
TL;DR: It is shown that the predicted transmembrane helix 4 of Escherichia coli FtsW is required for the transport activity of the protein, and two charged residues within this segment that are specifically involved in the flipping of Lipid II are identified.
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Fluorescence anisotropy assays for high throughput screening of compounds binding to lipid II, PBP1b, FtsW and MurJ
TL;DR: Interestingly, FA assay with lipid II probe has the advantage over moenomycin based probe to potentially identify compounds that interfere with both donor and acceptor sites of the aPBPs GTase as well as compounds that bind to lipid II.