Tamir Ben-Hur

TL;DR: The generation of enriched and expandable preparations of proliferating neural progenitors from human ES cells is reported, indicating that the transplanted cells migrated along established brain migratory tracks in the host brain and differentiated in a region-specific manner, indicating they could respond to local cues and participate in the processes of host brain development.

TL;DR: Transplantation of MSCs in patients with MS and ALS is a clinically feasible and relatively safe procedure and induces immediate immunomodulatory effects.

TL;DR: Elevation in brain IL-1 levels, which characterizes many medical conditions, is both necessary and sufficient for producing the high incidence of depression found in these conditions, and procedures aimed at reducing brain IL -1 levels may have potent antidepressive actions.

TL;DR: It is demonstrated that continuous administration of IL-1ra via osmotic minipumps during prenatal development disrupt memory performance in adult mice, suggesting thatIL-1 plays a critical role not only in the formation of hippocampal-dependent memory but also in normal hippocampal development.

TL;DR: The data indicate that the host‐lesioned striatum could not direct the transplanted neural progenitors to acquire a dopaminergic fate, and induction of their differentiation toward a midbrain fate prior to transplantation is probably required for complete correction of behavioral deficit.