Tammy L. McGuire

TL;DR: It is proposed that BMP-induced GFAP+ cells generated by LIF and BMP signaling are, respectively, adult progenitor cells and mature astrocytes in the non-neurogenic adult cortex.

TL;DR: It is proposed that the adult hippocampus contains a population of NSCs, which can be expanded both in vitro and in vivo by blocking B MP signaling, and blocking BMP signaling with Noggin is sufficient to foster hippocampal cell self-renewal, proliferation, and multipotentiality.

TL;DR: A novel role for microRNA-21 is demonstrated in regulating astrocytic hypertrophy and glial scar progression after SCI, and miR- 21 is suggested as a potential therapeutic target for manipulating gliosis and enhancing functional outcome.

TL;DR: It is found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages, suggesting that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation.

TL;DR: Regulation of microRNA-21 by BMP signaling provides a novel mechanism for regulation of astrocytic size and targeting specific BMPR subunits for therapeutic purposes may provide an approach for manipulating gliosis and enhancing functional outcomes after SCI.