Chian Yu Peng

TL;DR: It is proposed that the adult hippocampus contains a population of NSCs, which can be expanded both in vitro and in vivo by blocking B MP signaling, and blocking BMP signaling with Noggin is sufficient to foster hippocampal cell self-renewal, proliferation, and multipotentiality.

TL;DR: Insight is provided into the cell-extrinsic signaling that controls combinatorial transcription factor profiles involved in regulating the process of interneuron subtype diversification.

TL;DR: MiR-182 is identified as a regulator of apoptosis, growth, and differentiation programs whose expression level is correlated with GBM patient survival and harnessing the anti-tumor activities of miR- 182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM.

TL;DR: It is demonstrated that a large proportion of V2 interneurons expressed the axon guidance molecule EphA4, a molecule previously shown to be important for correct organization of locomotor networks, which enable a better interpretation of neural networks underlying locomotion, and open up the search for as yet unknown components of the mammalian central pattern generator.

TL;DR: It is shown that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxetine.