Tarik E. Ali

TL;DR: In this article, the authors showed that 5,6-diphenyl-3-hydrazino-1,2,4-triazine (1) with bis(methylthio)methylene]malononitrile (2) with benzoyl chloride and sodium pyruvate (3) with acetic anhydride produced pyrazolo[5,4,3-kl]pyrimido[4, 3-d]pyridine 6, which was allowed to react with hydrazine hydrate to give the corresponding hyd

TL;DR: In vitro antibacterial activities of the synthesized compounds exhibited good inhibitory activities against most the tested organisms with MIC values in the range 6.25-12.5 microg/mL and lower cytotoxicity in comparison with the reference drugs.

TL;DR: In this article, three series of novel fused nitrogen heterocyclic systems such as 1,2,4-triazolo[1,5-α ] pyridines (5-7 and 9), pyrido [1,2-b][1, 2,4]triazines (10, 11, 13 and 15), and pyridisensines (17, 18, 20 and 22) linked with a chromone moiety were synthesized from the key intermediate 1,6-diamino-(6-chloro-4-ox

TL;DR: Some new sulfur-nitrogen heterocyclic systems such as 1, 3-thiazoles, 1,3,4-thiadiazoles and 1, 2, 4-triazoles incorporating acridine and 1 2, 3, 4 -tetrahydroacridine moieties were synthesized via heterocycling of the key intermediate 4-(acridin-9-yl)-1-(1, 2.3, 4t, 4, 4)-thiosemicarbazide as discussed by the authors.

TL;DR: In this paper, a review of the chemical reactivity of 3-formylchromones towards condensation reactions with a variety of carbon and nitrogen nucleophiles is presented, which mainly proceed via condensation with the aldehydic function followed by nucleophilic attack at C-2 position of the chromone moiety.