Tathagat Dutta Ray

TL;DR: The findings suggest that RIP3 controls programmed necrosis by initiating the pronecrotic kinase cascade, and that this is necessary for the inflammatory response against virus infections.

TL;DR: It is shown in African green monkeys that systemic delivery of an anti-miRNA oligonucleotide that targets both miR-33a and miR/b increased hepatic expression of ABCA1 and induced a sustained increase in plasma HDL levels over 12 weeks, establishing a promising therapeutic strategy to raise plasma HDL and lower VLDL triglyceride levels for the treatment of dyslipidaemias that increase cardiovascular disease risk.

TL;DR: Netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated the migration of macrophage toward chemokines linked to their egress from plaques, establishing a causative role for negative regulators of leukocyte migration in chronic inflammation.

TL;DR: A mammalian miRNA circuit used by Mtb to coordinately inhibit autophagy and reprogram host lipid metabolism to enable intracellular survival and persistence in the host is defined.

TL;DR: It is shown that the neuroimmune guidance cue netrin-1 is highly expressed in obese but not lean adipose tissue of humans and mice, where it directs the retention of macrophages, and hematopoietic deletion of Ntn1 facilitates adipOSE tissue macrophage emigration, reduces inflammation and improves insulin sensitivity.