Janine M. van Gils

TL;DR: It is shown that oxidized LDL and amyloid-β trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6 that is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands.

TL;DR: It is established that raising HDL levels by anti-miR33 oligonucleotide treatment promotes reverse cholesterol transport and atherosclerosis regression and suggest that it may be a promising strategy to treat atherosclerotic vascular disease.

TL;DR: It is shown in African green monkeys that systemic delivery of an anti-miRNA oligonucleotide that targets both miR-33a and miR/b increased hepatic expression of ABCA1 and induced a sustained increase in plasma HDL levels over 12 weeks, establishing a promising therapeutic strategy to raise plasma HDL and lower VLDL triglyceride levels for the treatment of dyslipidaemias that increase cardiovascular disease risk.

TL;DR: An overview of these complex interactions between selectins and their ligands, and the integrins binding to Ig‐like cell adhesion molecules as well as to GP, present in the extracellular matrix or on activated endothelium are provided.

TL;DR: Netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated the migration of macrophage toward chemokines linked to their egress from plaques, establishing a causative role for negative regulators of leukocyte migration in chronic inflammation.