T
Tatsuhiko Yoshida
Researcher at University of Tokyo
Publications - 4
Citations - 678
Tatsuhiko Yoshida is an academic researcher from University of Tokyo. The author has contributed to research in topics: Herboxidiene & Precursor mRNA. The author has an hindex of 3, co-authored 4 publications receiving 620 citations.
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Journal ArticleDOI
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Daisuke Kaida,Hajime Motoyoshi,Etsu Tashiro,Takayuki Nojima,Masatoshi Hagiwara,Ken Ishigami,Hidenori Watanabe,Takeshi Kitahara,Tatsuhiko Yoshida,Hidenori Nakajima,Tokio Tani,Sueharu Horinouchi,Minoru Yoshida +12 more
TL;DR: The natural product FR901464 and its methylated derivative, spliceostatin A are shown to inhibit in vitro splicing and promote pre-mRNA accumulation by binding to SF3b, a subcomplex of the U2 small nuclear ribonucleoprotein in the spliceosome.
Journal ArticleDOI
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.
Yasushi Sakai,Tetsuya Tsujita,Tadakazu Akiyama,Tatsuhiko Yoshida,Tamio Mizukami,Shiro Akinaga,Sueharu Horinouchi,Minoru Yoshida,Tetsuo Yoshida +8 more
TL;DR: The results suggest that GEX1 compounds modulate gene expression by an unknown mechanism and show cytotoxic activities in the same order of the up-regulating activities on gene expression, suggesting that these two activities are related.
Journal ArticleDOI
Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes
Hajime Motoyoshi,Masato Horigome,Ken Ishigami,Tatsuhiko Yoshida,Sueharu Horinouchi,Minoru Yoshida,Hidenori Watanabe,Takeshi Kitahara +7 more
TL;DR: The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs and this method made it possible to synthesize biologically active FR 901464-biotin conjugates which could be used to isolate the binding proteins.
Journal ArticleDOI
GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. Part 2. The Effects on Cell Cycle Progression and Gene Expression.
Yasushi Sakai,Tetsuya Tsujita,Tadakazu Akiyama,Tatsuhiko Yoshida,Tamio Mizukami,Shiro Akinaga,Sueharu Horinouchi,Minoru Yoshida,Tetsuo Yoshida +8 more