Tatsuro Ikeuchi

TL;DR: Western blot analysis of human kidney medulla indicated that the molecular mass of hAQP-CD is 29 kD, which is the same mass expected from the amino acid sequence, which could be important for future studies of the pathophysiology of human urinary concentration mechanisms in normal and abnormal states.

TL;DR: The results suggest the following mechanisms for the development of colon tumors in patients with familial adenomatous polyposis: the heterozygous mutant/wild-type condition at the APC gene causes formation of mild or moderate adenoma, and the loss of the normal allele in theAPC gene leads to a change from moderate to severe adenomas.

TL;DR: Molecular analysis of BUB1B (encoding BubR1) in seven Japanese families with the PCS syndrome indicates the involvement of BubR 1 in p55cdc‐mediated mitotic checkpoint signaling, and suggest that >50% decrease in expression (or activity) ofbubR1 is involved in thePCS syndrome.

TL;DR: Investigation of Familial polyposis coli patients revealed frequent occurrence of allele loss on chromosome 22, with some additional losses on chromosomes 5, 6, 12q and 15, which suggests the possible involvement of more than one chromosomal locus in the development of familial and sporadic colon carcinomas.

TL;DR: Cytogenetic analysis detected deletions in chromosome 6q in five out of the six SNK cell clones, which suggested that a 6q deletion is a characteristic feature of EBV‐positive NK cells, which proliferated in the diseased individuals.