Taylor J. Jensen

TL;DR: It is reported that DNA methylation plays a role in the normal cell type-specific expression ofmiR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse.

TL;DR: A novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the underlying mechanism that allows for such statistical modeling is introduced.

TL;DR: A high-resolution promoter tiling array approach is used to analyze DNA methylation in breast cancer specimens and normal breast tissue to suggest that agglomerative epigenetic aberrations are frequent events in human breast cancer.

TL;DR: Changes in histone H3 acetylation occur during arsenical-induced malignant transformation that are linked to the expression state of the associated gene and suggest that arsenicals may participate in tumorigenesis by altering the epigenetic terrain of select genes.

TL;DR: Results show that large-scale epigenetic remodeling occurs in the earliest steps of mammary carcinogenesis, temporally links DNA methylation changes and overcoming cellular proliferation barriers, and provides a bank of potential epigenetic biomarkers that may prove useful in breast cancer risk assessment.