T
Teh Sheng Chan
Researcher at University of Texas Medical Branch
Publications - 4
Citations - 512
Teh Sheng Chan is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Pathogenesis & Transgene. The author has an hindex of 4, co-authored 4 publications receiving 448 citations.
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Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus Infection of Mice Transgenic for the Human Angiotensin-Converting Enzyme 2 Virus Receptor
Chien Te K. Tseng,Cheng Huang,Patrick C. Newman,Nan Wang,Krishna Narayanan,Douglas M. Watts,Shinji Makino,Michelle M. Packard,Sherif R. Zaki,Teh Sheng Chan,Clarence J. Peters +10 more
TL;DR: The severity of the disease that developed in these transgenic mice—AC70 in particular—makes these mouse models valuable not only for evaluating the efficacy of antivirals and vaccines, but also for studying SARS coronavirus pathogenesis.
Journal ArticleDOI
Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease
Anurodh S. Agrawal,Tania Garron,Xinrong Tao,Bi Hung Peng,Maki Wakamiya,Teh Sheng Chan,Robert B. Couch,Chien Te K. Tseng +7 more
TL;DR: It is shown that transgenic mice globally expressing hCD26/DPP4 were fully permissive to MERS-CoV infection, resulting in relentless weight loss and death within days postinfection, and this new and unique transgenic mouse model will be useful for furthering knowledge of MERS pathogenesis and for the development of vaccine and treatments against MSPV.
Journal ArticleDOI
Characterization and demonstration of the value of a lethal mouse model of Middle East respiratory syndrome coronavirus infection and disease
Xinrong Tao,Tania Garron,Anurodh S. Agrawal,Abdullah Algaissi,Bi Hung Peng,Maki Wakamiya,Teh Sheng Chan,Lu Lu,Lanying Du,Shibo Jiang,Robert B. Couch,Chien Te K. Tseng +11 more
TL;DR: A lethal transgenic mouse model of MERS-CoV infection and disease that globally expresses human CD26/DPP4 viral receptor is characterized and the value of this model for evaluating vaccines and antivirals against MERS is demonstrated.
Journal ArticleDOI
Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease.
Abdullah Algaissi,Abdullah Algaissi,Anurodh S. Agrawal,Song Han,Bi Hung Peng,Chuming Luo,Fang Li,Teh Sheng Chan,Robert B. Couch,Chien Te K. Tseng +9 more
TL;DR: It is suggested that the serum shDPP4 levels play a role in MERS pathogenesis and a potential of rshDPP 4 as a treatment option for MERS is demonstrated.