Teresa Reguly

TL;DR: BioGRID is a freely accessible database of physical and genetic interactions that includes >116 000 interactions from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens.

TL;DR: The Biological General Repository for Interaction Datasets (BioGRID) is an open access archive of genetic and protein interactions that are curated from the primary biomedical literature for all major model organism species.

TL;DR: The BioGRID 3.0 web interface contains new search and display features that enable rapid queries across multiple data types and sources that enable insights into conserved networks and pathways that are relevant to human health.

TL;DR: The BioGRID architecture has been improved to support a broader range of interaction and post-translational modification types, to allow the representation of more complex multi-gene/protein interactions, to account for cellular phenotypes through structured ontologies, to expedite curation through semi-automated text-mining approaches, and to enhance curation quality control.

TL;DR: A kinase and phosphatase interaction (KPI) network of 1844 interactions in budding yeast was identified by mass spectrometric analysis of protein complexes and contained many dense local regions of interactions that suggested new functions.