B
Brett Larsen
Researcher at Mount Sinai Hospital, Toronto
Publications - 28
Citations - 4171
Brett Larsen is an academic researcher from Mount Sinai Hospital, Toronto. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 23 publications receiving 3846 citations. Previous affiliations of Brett Larsen include Mount Sinai Hospital & Lunenfeld-Tanenbaum Research Institute.
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Journal ArticleDOI
A global protein kinase and phosphatase interaction network in yeast.
Ashton Breitkreutz,Hyungwon Choi,Jeffrey R. Sharom,Lorrie Boucher,Victor Neduva,Brett Larsen,Zhen Yuan Lin,Bobby Joe Breitkreutz,Chris Stark,Guomin Liu,Jessica Ahn,Danielle Dewar-Darch,Teresa Reguly,Xiaojing Tang,Ricardo Almeida,Zhaohui S. Qin,Tony Pawson,Anne-Claude Gingras,Alexey I. Nesvizhskii,Mike Tyers +19 more
TL;DR: A kinase and phosphatase interaction (KPI) network of 1844 interactions in budding yeast was identified by mass spectrometric analysis of protein complexes and contained many dense local regions of interactions that suggested new functions.
Journal ArticleDOI
SAINT: probabilistic scoring of affinity purification-mass spectrometry data
Hyungwon Choi,Brett Larsen,Zhen Yuan Lin,Ashton Breitkreutz,Dattatreya Mellacheruvu,Damian Fermin,Zhaohui S. Qin,Zhaohui S. Qin,Mike Tyers,Anne-Claude Gingras,Alexey I. Nesvizhskii +10 more
TL;DR: 'Significance analysis of interactome' (SAINT), a computational tool that assigns confidence scores to protein-protein interaction data generated using affinity purification–mass spectrometry (AP-MS), is presented.
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The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway
Xaralabos Varelas,Payman Samavarchi-Tehrani,Payman Samavarchi-Tehrani,Masahiro Narimatsu,Alexander Weiss,Katie Cockburn,Brett Larsen,Janet Rossant,Jeffrey L. Wrana,Jeffrey L. Wrana +9 more
TL;DR: It is demonstrated that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity complexes, and that disruption of the Crumbs complex enhances TGF-β signaling and predisposes cells to T GF-β-mediated epithelial-to-mesenchymal transitions.
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The cell-cycle regulatory protein Cks1 is required for SCF Skp2 -mediated ubiquitinylation of p27
TL;DR: It is shown that the missing factor is CDK subunit 1 (Cks1), which belongs to the highly conserved Suc1/Cks family of proteins that bind to some CDKs and phosphorylated proteins and are essential for cell-cycle progression.
Journal ArticleDOI
A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein
Marilyn Goudreault,Lisa M. D'Ambrosio,Lisa M. D'Ambrosio,Michelle J. Kean,Michelle J. Kean,Michael Mullin,Brett Larsen,Amy Sanchez,Sidharth Chaudhry,Ginny I. Chen,Ginny I. Chen,Frank Sicheri,Frank Sicheri,Alexey I. Nesvizhskii,Ruedi Aebersold,Ruedi Aebersold,Brian Raught,Anne-Claude Gingras,Anne-Claude Gingras +18 more
TL;DR: A novel large multiprotein assembly, referred to as the striatin-interacting phosphatase and kinase (STRIPAK) complex, which contains the PP2A catalytic and scaffolding subunits, and members of the germinal center kinase III family of Ste20 kinases.