T
Terrence X. O'Brien
Researcher at Medical University of South Carolina
Publications - 42
Citations - 2849
Terrence X. O'Brien is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Heart failure & Purkinje fibers. The author has an hindex of 22, co-authored 41 publications receiving 2718 citations. Previous affiliations of Terrence X. O'Brien include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Transcriptional regulation during cardiac growth and development.
Kenneth R. Chien,Hong Zhu,Kirk U. Knowlton,W.C. Miller-Hance,M. Van-Bilsen,Terrence X. O'Brien,Sylvia M. Evans +6 more
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The Effect of Alagebrium Chloride (ALT-711), a Novel Glucose Cross-Link Breaker, in the Treatment of Elderly Patients With Diastolic Heart Failure
William C. Little,Michael R. Zile,Dalane W. Kitzman,W. Gregory Hundley,Terrence X. O'Brien,Robert C. deGroof +5 more
TL;DR: Sixteen weeks of treatment with the glucose crosslink breaker, alagebrium, resulted in a decrease in left ventricular mass and improvements inleft ventricular diastolic filling and quality of life in patient with DHF.
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Coronary CT angiography: image quality, diagnostic accuracy, and potential for radiation dose reduction using a novel iterative image reconstruction technique—comparison with traditional filtered back projection
Antonio Moscariello,Antonio Moscariello,Richard A.P. Takx,Richard A.P. Takx,U. Joseph Schoepf,Matthias Renker,Peter L. Zwerner,Terrence X. O'Brien,Terrence X. O'Brien,Thomas Allmendinger,Sebastian Vogt,Bernhard Schmidt,Giancarlo Savino,C Fink,C Fink,Lorenzo Bonomo,Thomas Henzler,Thomas Henzler +17 more
TL;DR: Iterative reconstruction significantly reduces image noise without loss of diagnostic information and holds the potential for substantial radiation dose reduction from cCTA.
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Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
Patrick Y. Jay,Brett S. Harris,Colin T. Maguire,Antje Buerger,Hiroko Wakimoto,Makoto Tanaka,Sabina Kupershmidt,Dan M. Roden,Thomas M. Schultheiss,Terrence X. O'Brien,Robert G. Gourdie,Charles I. Berul,Seigo Izumo +12 more
TL;DR: It is shown in KO mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 gene dosage, and it is surprising that the cellular expression of connexin40, the major gap junction isoform of Purkinje fibers and a putative Nk x 2-5 target, is unaffected.
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Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube
TL;DR: Evidence is provided for early positional specification of MLC-2v gene expression in the primitive heart tube and indicates regional specification of part of the ventricular muscle gene program can precede ventricular septation during mammalian cardiogenesis.