T
Terry Lechler
Researcher at Duke University
Publications - 62
Citations - 4095
Terry Lechler is an academic researcher from Duke University. The author has contributed to research in topics: Adherens junction & Microtubule. The author has an hindex of 29, co-authored 60 publications receiving 3616 citations. Previous affiliations of Terry Lechler include Harvard University & Howard Hughes Medical Institute.
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Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Terry Lechler,Elaine Fuchs +1 more
TL;DR: It is shown that basal epidermal cells use their polarity to divide asymmetrically, generating a committed suprabasal cell and a proliferative basal cell and it is demonstrated that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3–LGN–Inscuteable complex and NuMA–dynactin to align the spindle.
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Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein.
TL;DR: It is shown that Bee1p and the Arp2/3 complex co-immunoprecipitate when expressed at endogenous levels, and that this interaction requires both the Arc15p and Arc19p subunits of the ArP2/ 3 complex.
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Direct Involvement of Yeast Type I Myosins in Cdc42-Dependent Actin Polymerization
TL;DR: Combined deletions of the Arp2/3-interacting domains of Bee1p and the type I myosins abolish actin nucleation sites at the cortex, suggesting that these proteins function redundantly in the activation of the actin-related protein Arp 2/3 complex.
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Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses
TL;DR: These findings suggest that, if no compensatory mechanisms exist, E-cadherin loss may be incompatible with epithelial tissue survival, whereas partial compensation can result in alterations in differentiation and proliferation.
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Desmoplakin: an unexpected regulator of microtubule organization in the epidermis
Terry Lechler,Elaine Fuchs +1 more
TL;DR: A differentiation-specific rearrangement of the microtubule cytoskeleton in epidermis is uncovers, and an essential role for desmoplakin is defined in the process.