H. Amalia Pasolli

TL;DR: It is shown that HG cells are derived from bulge stem cells (SCs) but become responsive quicker to DP-promoting signals, and also proliferate sooner but display shorter-lived potential than bulge cells.

TL;DR: Together, these studies reveal that PRCs control epigenetic modifications temporally and spatially in tissue-restricted stem cells and maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion.

TL;DR: Combining purification and gene expression analysis with differential ablation and functional experiments, these non-SC niche residents are defined and the intriguing concept that an irreversibly committed cell in an SC lineage can become an essential contributor to the niche microenvironment is unveiled.

TL;DR: It is shown that slow-cycling cells appear early in skin development, express SC markers, and later give rise to the adult SC population, which establishes the existence of early hair follicle SCs and reveals their physiological importance in tissue morphogenesis.

TL;DR: An early role for RBP-J and Notch in commitment of epidermal cells to terminally differentiate is uncovered and it is revealed that spinous gene induction is mediated by a Hes1-dependent mechanism, while basal gene repression occurs independently of Hes1.