R
Rong Li
Researcher at Johns Hopkins University School of Medicine
Publications - 178
Citations - 17149
Rong Li is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Arp2/3 complex & Actin. The author has an hindex of 68, co-authored 165 publications receiving 15689 citations. Previous affiliations of Rong Li include Discovery Institute & Johns Hopkins University.
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Journal ArticleDOI
Feedback control of mitosis in budding yeast.
Rong Li,Andrew W. Murray +1 more
TL;DR: The role of feedback controls in coordinating events in the cell cycle is discussed and the properties of mad mutants indicate that they are defective in the feedback control over the exit from mitosis are discussed.
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Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.
Norman Pavelka,Giulia Rancati,Jin Zhu,William D. Bradford,Anita Saraf,Laurence Florens,Brian W. Sanderson,Gaye Hattem,Rong Li,Rong Li +9 more
TL;DR: It is shown, using quantitative mass spectrometry-based proteomics and phenotypic profiling, that levels of protein expression in aneuploid yeast strains largely scale with chromosome copy numbers, following the same trend as that observed for the transcriptome, and that aneuPLoidy confers diverse phenotypes.
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Activation of Arp2/3 complex-mediated actin polymerization by cortactin.
TL;DR: It is shown that cortactin co-localizes with the Arp2/3 complex, a de novo actin nucleator, at dynamic particulate structures enriched with actin filaments.
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Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility
Coumaran Egile,Thomas P. Loisel,Valérie M. Laurent,Rong Li,Dominique Pantaloni,Philippe J. Sansonetti,Marie-France Carlier +6 more
TL;DR: It is shown here that the bacterial protein IcsA binds N-WASP and activates it in a Cdc42-like fashion, which unmasks two domains acting together in insertional actin polymerization.
Journal ArticleDOI
Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions
TL;DR: This work investigates why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops.