T
Teruhiko Wakayama
Researcher at University of Yamanashi
Publications - 259
Citations - 19404
Teruhiko Wakayama is an academic researcher from University of Yamanashi. The author has contributed to research in topics: Somatic cell & Embryonic stem cell. The author has an hindex of 64, co-authored 247 publications receiving 18478 citations. Previous affiliations of Teruhiko Wakayama include Rockefeller University & Kwansei Gakuin University.
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Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei
Teruhiko Wakayama,Anthony C.F. Perry,Anthony C.F. Perry,Maurizio Zuccotti,Maurizio Zuccotti,K R Johnson,Ryuzo Yanagimachi +6 more
TL;DR: These experiments show that for mammals, nuclei from terminally differentiated, adult somatic cells of known phenotype introduced into enucleated oocytes are capable of supporting full development.
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Differentiation of Embryonic Stem Cell Lines Generated from Adult Somatic Cells by Nuclear Transfer
Teruhiko Wakayama,Viviane Tabar,Ivan Rodriguez,Anthony C.F. Perry,Lorenz Studer,T. Peter Mombaerts +5 more
TL;DR: These studies demonstrate the full pluripotency of ntES cells, which have contributed to an extensive variety of cell types, including dopaminergic and serotonergic neurons in vitro and germ cells in vivo.
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Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning.
Xiangzhong Yang,Sadie L. Smith,X. Cindy Tian,Harris A. Lewin,Jean-Paul Renard,Teruhiko Wakayama +5 more
TL;DR: The recent literature on nuclear reprogramming by SCNT is reviewed, including studies of gene expression, DNA methylation, chromatin remodeling, genomic imprinting and X chromosome inactivation, which seems to be highly efficient.
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Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer
Satoshi Kishigami,Eiji Mizutani,Hiroshi Ohta,Takafusa Hikichi,Nguyen Van Thuan,Sayaka Wakayama,Hong-Thuy Bui,Teruhiko Wakayama +7 more
TL;DR: It is found that 5-50 nM TSA-treatment for 10 h following oocyte activation resulted in more efficient in vitro development of somatic cloned embryos to the blastocyst stage from 2- to 5-fold depending on the donor cells including tail tip cells, spleen cells, neural stem cells, and cumulus cells.