T
Thazin Nwe Aung
Researcher at Yale University
Publications - 47
Citations - 643
Thazin Nwe Aung is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Compound Kushen Injection. The author has an hindex of 7, co-authored 27 publications receiving 339 citations. Previous affiliations of Thazin Nwe Aung include University of Adelaide & UPRRP College of Natural Sciences.
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Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action
TL;DR: In vitro data suggest that in vitro data for natural compound mixtures believed to have multiple specific targets with minimal acceptable side-effects merit further investigation, both in vitro and in vivo.
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Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics
Zhipeng Qu,Jian Cui,Yuka Harata-Lee,Thazin Nwe Aung,Qianjin Feng,Joy M. Raison,Robert Daniel Kortschak,David L. Adelson +7 more
TL;DR: This report shows that CKI inhibited MCF-7 cell proliferation and induced apoptosis in a dose-dependent fashion and identified novel lncRNAs and showed that many of them might be expressed as a response to CKI treatment.
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STING enhances cell death through regulation of reactive oxygen species and DNA damage
Thomas J. Hayman,Marta Baro,Tyler MacNeil,Chatchai Phoomak,Thazin Nwe Aung,Wei Cui,Kevin Leach,Radhakrishnan P. Iyer,Sreerupa Challa,Teresa Sandoval-Schaefer,Barbara Burtness,David L. Rimm,Joseph N. Contessa +12 more
TL;DR: In this article, a CRISPR-Cas9 screen using ionizing radiation as a selective pressure was performed to identify unrecognized regulators of cell survival and identified STING (stimulator of interferon genes) as an intrinsic regulator of tumor cell survival.
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MicroRNA-124 regulates glucocorticoid sensitivity by targeting phosphodiesterase 4B in diffuse large B cell lymphoma.
TL;DR: This study shows that miR-124 influences GC-induced apoptosis by directly targeting PDE4B, and supports the notion that this miRNA could be an attractive therapeutic target for overcoming GC resistance in DLBCL.
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Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection
TL;DR: The results demonstrate that CKI can suppress protein levels for cell cycle regulatory proteins and DNA repair while increasing the level of DSBs, and show that energy metabolism is reduced based on reduced glucose consumption and reduced cellular energy charge.