Thierry Chataigneau

TL;DR: The current evidence suggests that all these mechanisms are triggered by polyphenols with specific structures, although the structural requirements may be different from one effect to the other, and that they all contribute to the vasoprotective,Anti-angiogenic, anti-atherogenic, vasorelaxant and anti-hypertensive effects of acute or chronic administration of plant polyphenol found in vivo in animals and in patients.

TL;DR: It is demonstrated that in the blood vessels studied, the endothelium‐dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo‐oxygenase but not EDHF; in the eNOS(−/−) mice, NO‐dependent responses and EDHF‐like responses were not observed.

TL;DR: It is demonstrated that RWPs induce the redox‐sensitive activation of the PI3‐kinase/Akt pathway in endothelial cells which, in turn, causes phosphorylation of eNOS, resulting in an increased formation of NO.

TL;DR: In this article, the authors examined whether red wine polyphenols prevent the angiotensin II (Ang II)-induced hypertension and endothelial dysfunction in rats, and, if so, to elucidate the underlying mechanism.

TL;DR: Results suggest a new role of ICBP90 in the relationship between histone ubiquitination and DNA methylation in the context of tumoral angiogenesis and tumour suppressor genes silencing and co-immunoprecipitation experiments showed thatICBP90 and DNMT1 are present in the same molecular complex, which was further confirmed by co-localization experiments as assessed by immunocytochemistry.