T
Thomas Brücke
Researcher at University of Vienna
Publications - 88
Citations - 5770
Thomas Brücke is an academic researcher from University of Vienna. The author has contributed to research in topics: Dopamine receptor D2 & Parkinson's disease. The author has an hindex of 36, co-authored 88 publications receiving 5449 citations.
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Journal ArticleDOI
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich,Anna Benet-Pagès,Walter Struhal,Elisabeth Graf,Sebastian H. Eck,Marc N. Offman,Dietrich Haubenberger,Sabine Spielberger,Eva C. Schulte,Peter Lichtner,Shaila C. Rossle,Norman Klopp,Elisabeth Wolf,Klaus Seppi,Walter Pirker,Stefan Presslauer,Brit Mollenhauer,Regina Katzenschlager,Thomas Foki,Christoph Hotzy,Eva M. Reinthaler,Ashot S. Harutyunyan,Robert Kralovics,Annette Peters,Fritz Zimprich,Thomas Brücke,Werner Poewe,Eduard Auff,Claudia Trenkwalder,Burkhard Rost,Gerhard Ransmayr,Juliane Winkelmann,Thomas Meitinger,Tim M. Strom +33 more
TL;DR: An Austrian family with 16 affected individuals by exome sequencing found a missense mutation, c.1858G>A (p.Asp620Asn), in the VPS35 gene in all seven affected family members who are alive, and found the same variant cosegregating with the disease in an autosomal-dominant mode with high but incomplete penetrance.
Journal ArticleDOI
The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study)
Claustre Pont-Sunyer,Anna Hotter,Carles Gaig,Klaus Seppi,Yaroslau Compta,Regina Katzenschlager,Natalia Mas,Dominik Hofeneder,Thomas Brücke,Àngels Bayés,Karoline Wenzel,Jon Infante,Heidemarie Zach,Walter Pirker,Ignacio J. Posada,Ramiro Álvarez,Lourdes Ispierto,Oriol De Fabregues,Antoni Callén,Antoni Palasí,Miquel Aguilar,María José Martí,Francesc Valldeoriola,Manel Salamero,Werner Poewe,Eduardo Tolosa +25 more
TL;DR: Nonmotor symptoms (NMS) in Parkinson's disease (PD) are common in early unmedicated PD and frequently reported to occur in the premotor period, but a patient subgroup showed high NMS burden mainly resulting from cognition‐related symptoms.
Journal ArticleDOI
Dopamine D2 Receptor Imaging with SPECT: Studies in Different Neuropsychiatric Disorders
Thomas Brücke,Ivo Podreka,Peter Angelberger,S. Wenger,A. Topitz,B. Küfferle,Ch. Müller,Lüder Deecke +7 more
TL;DR: The results show that dopamine D2 receptors can be clearly visualized with high resolution using the SPECT technique and S-(–)-IBZM as a ligand and is of clinical value for the diagnosis of degenerative neurological disorders such as Huntington's disease and for the monitoring of neuroleptic treatment.
Journal Article
Initial experience with technetium-99m HM-PAO brain SPECT.
Ivo Podreka,E. Suess,Georg Goldenberg,M. Steiner,Thomas Brücke,Ch. Müller,Wilfried Lang,R.D. Neirinckx,Lüder Deecke +8 more
TL;DR: The results indicate that [99mTc]HM-PAO SPECT is valuable for demonstrating pathologic and physiologic changes of the brain.
Journal ArticleDOI
[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Walter Pirker,Susanne Asenbaum,Gerhard Bencsits,Daniela Prayer,Willibald Gerschlager,Lüder Deecke,Thomas Brücke +6 more
TL;DR: In conclusion, [123I]β‐CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD.