T
Thomas C. Merigan
Researcher at Stanford University
Publications - 515
Citations - 34283
Thomas C. Merigan is an academic researcher from Stanford University. The author has contributed to research in topics: Interferon & Virus. The author has an hindex of 98, co-authored 514 publications receiving 33941 citations. Previous affiliations of Thomas C. Merigan include University of Arizona & Rockefeller Institute of Government.
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Interferon induction in man by a synthetic polyanion of defined composition.
TL;DR: Although human interferon can be produced in tissue culture and appears during a variety of Naturally occurring and artificially induced virus infections in man – both in serum and in infected tissue – it has not been obtained in quantities sufficient for treatment of naturally occurring virus infections.
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Viral polypeptides detected by a complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus.
TL;DR: Murine monoclonal antibodies were produced which coimmunoprecipitated, under reducing conditions, 130,000- and 55, thousands-dalton (Da) polypeptides from cells infected with human cytomegalovirus (CMV) strain AD169, which neutralized CMV AD169 only in the presence of guinea pig complement.
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“Wide-Open” 1.3 Å Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target
Philip D. Martin,John F. Vickrey,Gheorghe Proteasa,Yurytzy L. Jimenez,Zdzislaw Wawrzak,Mark A. Winters,Thomas C. Merigan,Ladislau C. Kovari +7 more
TL;DR: This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor.
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Drug Resistance and Heterogeneous Long-Term Virologic Responses of Human Immunodeficiency Virus Type 1-Infected Subjects to Zidovudine and Didanosine Combination Therapy
Robert W. Shafer,Astrid K. N. Iversen,Mark A. Winters,Elsa Aguiniga,David Katzenstein,Thomas C. Merigan +5 more
TL;DR: HIV resistance mechanisms during combination therapy appear more complex than reported with monotherapy andeterogeneity exists among individual virologic responses to zidovudine and didanosine combination therapy.
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Suppression of mouse antibody producing spleen cells by various interferon preparations.
TL;DR: Polyribocytidylic acid, endotoxin, polycarboxylate plastics or polysaccharides, and other polyanions induce interferon production and enhance antibody production, cell-mediated immunity, and reticuloendothelial activity.