T
Thomas C. Merigan
Researcher at Stanford University
Publications - 515
Citations - 34283
Thomas C. Merigan is an academic researcher from Stanford University. The author has contributed to research in topics: Interferon & Virus. The author has an hindex of 98, co-authored 514 publications receiving 33941 citations. Previous affiliations of Thomas C. Merigan include University of Arizona & Rockefeller Institute of Government.
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Journal ArticleDOI
Treatment Of NZB/NZW F1 Hybrid Mice with Mycobacterium Bovis Strain BCG or Type II Interferon Preparations Accelerates Autoimmune Disease
Edgar G. Engleman,Gerald Sonnenfeld,Michael J. Dauphinee,John S. Greenspan,Norman Talal,Hugh O. McDevitt,Thomas C. Merigan +6 more
TL;DR: Type II interferon may play a role in the pathogenesis of autoimmune disease and the increased death rate was associated with a more rapid development of antinuclear antibodies and histologically confirmed glomerulonephritis.
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Changes in CD4+ and CD8+ T cell subsets in response to highly active antiretroviral therapy in HIV type 1-infected patients with prior protease inhibitor experience.
TL;DR: Overall, drug-experienced patients responding to HAART displayed increased numbers of naive and memory CD4+ subsets, and reduced CD8+ cell activation with a loss of TCR skewing, which was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART).
Journal Article
Natural killing in estrogen-treated mice responds poorly to poly i.c Despite normal stimulation of circulating interferon.
TL;DR: Estradiol does not block interferon production but does suppress the response of natural killer cells to interferons, and it is suggested that estrogens either block the maturation of natural Killer cells or reduce the number of naturalkiller cell precursors.
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Detection Of Drug Resistance Mutations In The Human Immunodeficiency Virus Type I (HIV-I) pol Gene: Differences In Semen And Blood HIV-I RNA And Proviral DNA
TL;DR: Study of the appearance of HIV-1 mutations in various compartments may help elucidate how the populations and dynamics of the virus differ throughout the body and determine whether seminal cell-free virus or provirus is the major sexually transmitted form.
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Lymphocyte transformation and interferon production in human mononuclear cell microcultures for assay of cellular immunity to herpes simplex virus.
TL;DR: Significant differences in transformation and interferon were observed between donors with a history of herpes labialis and donors with no detectable antibody, both in cultures prepared by Ficoll-Hypaque gradients and by column purification of lymphocytes.