T
Thomas E. Cheatham
Researcher at University of Utah
Publications - 164
Citations - 38522
Thomas E. Cheatham is an academic researcher from University of Utah. The author has contributed to research in topics: Molecular dynamics & Nucleic acid. The author has an hindex of 58, co-authored 156 publications receiving 32976 citations. Previous affiliations of Thomas E. Cheatham include Free University of Berlin & University of California, San Francisco.
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Molecular dynamics re-refinement of two different small RNA loop structures using the original NMR data suggest a common structure
TL;DR: Re-investigating the solution structures of two RNA hairpins that had previously been refined using conventional techniques suggests that restrained MD simulations, with proper caution, can be used to “update” older structures or aid in the refinement of new structures that lack sufficient experimental data.
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Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.
TL;DR: Investigation of the scope of leaving groups that are compatible with benzonorbornadienes with different releasable groups is investigated, and the reaction of these molecules with tetrazine was found to be rapid and afforded high release yields.
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Consensus Conformations of Dinucleoside Monophosphates Described with Well-Converged Molecular Dynamics Simulations.
TL;DR: A temperature replica-exchange molecular dynamics approach is applied to fully and quickly converge conformational distributions of all RNA DNMPs immersed in the TIP3P water model using the AMBER ff14 force field to foresee such effects in larger RNA motifs including tetranucleotides and tetraloops.
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Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.
Andrew S. Dixon,Geoffrey D. Miller,Benjamin J. Bruno,Jonathan E. Constance,David W. Woessner,Trevor P. Fidler,James C. Robertson,Thomas E. Cheatham,Carol S. Lim +8 more
TL;DR: CCmut3 demonstrated improved oligomerization via a two-hybrid assay as well as through colocalization studies, in addition to showing similar biologic activity as CCmut2, and may be used to redirect Bcr-Abl to alternative subcellular locations with interesting therapeutic implications.
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Stem-Loop V of Varkud Satellite RNA Exhibits Characteristics of the Mg(2+) Bound Structure in the Presence of Monovalent Ions.
TL;DR: The Varkud Satellite RNA contains a self-cleaving ribozyme that has been shown to function independently of its surroundings, and it is proposed this structure is a “gatekeeper” or precursor to Mg2+ binding when those ions are present.