T
Thomas Guilbert
Researcher at University of Paris
Publications - 29
Citations - 576
Thomas Guilbert is an academic researcher from University of Paris. The author has contributed to research in topics: Extracellular matrix & Stimulator of interferon genes. The author has an hindex of 9, co-authored 29 publications receiving 333 citations. Previous affiliations of Thomas Guilbert include French Institute of Health and Medical Research & Paris Descartes University.
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Journal ArticleDOI
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.
Alba Nicolas-Boluda,Javier Vaquero,Lene Vimeux,Thomas Guilbert,Sarah Barrin,Chahrazade Kantari-Mimoun,Matteo Ponzo,Gilles Renault,Piotr Deptuła,Katarzyna Pogoda,Robert Bucki,Ilaria Cascone,José Courty,Laura Fouassier,Florence Gazeau,Emmanuel Donnadieu +15 more
TL;DR: In this article, the authors compared five preclinical mouse tumor models with heterogeneous tumor microenvironments and found that the rate of tumor stiffening with the remodeling of extracellular matrix (ECM) architecture and how these features affect intratumoral T cell migration.
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The Wnt/Planar Cell Polarity Signaling Pathway Contributes to the Integrity of Tight Junctions in Brain Endothelial Cells
Cédric Artus,Fabienne Glacial,Kayathiri Ganeshamoorthy,Nicole Ziegler,Maeva Godet,Thomas Guilbert,Stefan Liebner,Pierre-Olivier Couraud +7 more
TL;DR: This study suggests that the Wnt/Par/aPKC PCP pathway, in addition to theWnt/β-catenin canonical pathway, is a key regulator of the BBB.
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Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Nadira Ruzehaji,Camelia Frantz,Matthieu Ponsoye,Jérôme Avouac,Jérôme Avouac,Jérôme Avouac,Sonia Pezet,Thomas Guilbert,Thomas Guilbert,Thomas Guilbert,Jean-Michel Luccarini,Pierre Broqua,Jean-Louis Junien,Yannick Allanore,Yannick Allanore,Yannick Allanore +15 more
TL;DR: Findings indicate that simultaneous activation of all three PPAR isoforms exerts a dampening effect on inflammation and fibrosis, making IVA337 a potentially effective therapeutic candidate in the treatment of fibrotic diseases including SSc.
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How Tissue Mechanical Properties Affect Enteric Neural Crest Cell Migration
Nicolas Chevalier,Elodie Gazguez,Laurent Bidault,Thomas Guilbert,C. Vias,Emmanuel Vian,Yuli Watanabe,Laurent Muller,Stéphane Germain,Nadege Bondurand,Simon Dufour,Vincent Fleury +11 more
TL;DR: Light is shed on the role of the mechanical properties of tissues in ENCC migration during development by showing using tensile stretching and atomic force microscopy that the mesenchyme of the gut was initially soft but gradually stiffened during the period of ENCC colonization.
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The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking
Audrey Dumas,Gabrielle Lê-Bury,Gabrielle Lê-Bury,Gabrielle Lê-Bury,Florence Marie-Anaïs,Florence Marie-Anaïs,Florence Marie-Anaïs,Floriane Herit,Floriane Herit,Floriane Herit,Julie Mazzolini,Julie Mazzolini,Julie Mazzolini,Thomas Guilbert,Thomas Guilbert,Thomas Guilbert,Pierre Bourdoncle,Pierre Bourdoncle,Pierre Bourdoncle,David G. Russell,Serge Benichou,Serge Benichou,Serge Benichou,Ahmed Zahraoui,Ahmed Zahraoui,Ahmed Zahraoui,Florence Niedergang,Florence Niedergang,Florence Niedergang +28 more
TL;DR: The HIV protein Vpr interacts with EB1, p150Glued, and dynein heavy chain and perturbs the centripetal movement of phagosomes and their maturation, resulting in impaired phagolysosome biogenesis, which is important for bacterial clearance and cytokine production.