T
Thomas H. LaBean
Researcher at North Carolina State University
Publications - 125
Citations - 10235
Thomas H. LaBean is an academic researcher from North Carolina State University. The author has contributed to research in topics: DNA nanotechnology & DNA origami. The author has an hindex of 43, co-authored 121 publications receiving 9597 citations. Previous affiliations of Thomas H. LaBean include University of North Carolina at Chapel Hill & Duke University.
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DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
TL;DR: A DNA nanostructure consisting of four four-arm junctions oriented with a square aspect ratio was designed and constructed in this article, where programmable self-assembly of 4 × 4 tiles resulted in two distinct lattice morphologies: uniform-width nanoribbons and two-dimensional nanogrids, which both display periodic square cavities.
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Logical computation using algorithmic self-assembly of DNA triple-crossover molecules
TL;DR: A one-dimensional algorithmic self-assembly of DNA triple-crossover molecules that can be used to execute four steps of a logical (cumulative XOR) operation on a string of binary bits is reported.
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Construction, analysis, ligation, and self-assembly of DNA triple crossover complexes
Thomas H. LaBean,Hao Yan,Jens Kopatsch,Furong Liu,Erik Winfree,John H. Reif,Nadrian C. Seeman +6 more
TL;DR: The DNA triple crossover (TX) complex described here extends the set of experimentally characterized building blocks and allows for the presence of reporter strands along the molecular diagonal that can be used to relate the inputs and outputs of DNA-based computation.
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Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms.
Word Jm,Simon C. Lovell,Thomas H. LaBean,Hope C. Taylor,Michael E. Zalis,Presley Bk,Jane S. Richardson,David S. Richardson +7 more
TL;DR: It was determined that, in general, methyl groups pack well in the default staggered conformation, except for the terminal methyl groups of methionine residues, which required rotational optimization, and high-resolution structures show impressively well-fitted packing interactions.
Journal ArticleDOI
Programming DNA Tube Circumferences
Peng Yin,Rizal F. Hariadi,Sudheer Sahu,Harry M. T. Choi,Sung Ha Park,Thomas H. LaBean,John H. Reif +6 more
TL;DR: This work program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif by single-step annealing.