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Thomas J. Beauchamp
Researcher at University of Pennsylvania
Publications - 12
Citations - 506
Thomas J. Beauchamp is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Discodermolide & Scale (ratio). The author has an hindex of 6, co-authored 12 publications receiving 499 citations. Previous affiliations of Thomas J. Beauchamp include Monell Chemical Senses Center.
Papers
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Journal ArticleDOI
Evolution of a gram-scale synthesis of (+)-discodermolide
Amos B. Smith,Thomas J. Beauchamp,Matthew J. LaMarche,Michael D. Kaufman,Yuping Qiu,Hirokazu Arimoto,David R. Jones,Kaoru Kobayashi +7 more
TL;DR: An efficient, highly convergent, stereocontrolled total synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on gram scale.
Journal ArticleDOI
Gram-scale synthesis of (+)-discodermolide.
TL;DR: A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide has been achieved on a 1-g scale.
Journal ArticleDOI
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies
Laura A. Martello,Matthew J. LaMarche,Lifeng He,Thomas J. Beauchamp,Amos B. Smith,Susan Band Horwitz +5 more
TL;DR: Interestingly, (+)-discodermolide demonstrates a profound enhancement of the initiation process of microtubule polymerization compared to Taxol, and has a similar ability to stabilize microtubules in Taxol-resistant cells.
Journal ArticleDOI
Phorboxazole Synthetic Studies. 2. Construction of a C(20−28) Subtarget, a Further Extension of the Petasis−Ferrier Rearrangement
TL;DR: This, the second of two Letters, describes the efficient assembly of (+)-4, a C(20-28) subtarget for the total synthesis of phorboxazoles A and B and a new tactic for the synthesis of enol ethers based on the elegant work of Julia is described.
Patent
Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
Amos B. Smith,Yuping Qiu,Michael Kaufman,Hirokazu Arimoto,David R. Jones,Kaoru Kobayashi,Thomas J. Beauchamp +6 more
TL;DR: Synthetic methods for lactone-containing compounds such as discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation as discussed by the authors.