D
David R. Jones
Researcher at University of Pennsylvania
Publications - 12
Citations - 433
David R. Jones is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Discodermolide & Crystal structure. The author has an hindex of 7, co-authored 12 publications receiving 427 citations. Previous affiliations of David R. Jones include Monell Chemical Senses Center.
Papers
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Journal ArticleDOI
Evolution of a gram-scale synthesis of (+)-discodermolide
Amos B. Smith,Thomas J. Beauchamp,Matthew J. LaMarche,Michael D. Kaufman,Yuping Qiu,Hirokazu Arimoto,David R. Jones,Kaoru Kobayashi +7 more
TL;DR: An efficient, highly convergent, stereocontrolled total synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on gram scale.
Journal ArticleDOI
Langmuir films of fullerene C60, fullerene epoxide C60O, and dihydrofulleroid C61H2
Nicholas C. Maliszewskyj,Paul A. Heiney,David R. Jones,Robert M. Strongin,M. A. Cichy,Amos B. Smith +5 more
Journal ArticleDOI
The orientational phase transition in solid buckminsterfullerene epoxide (C60O)
Gavin Vaughan,Paul A. Heiney,David E. Cox,Andrew R. McGhie,David R. Jones,Robert M. Strongin,M. A. Cichy,Amos B. Smith +7 more
TL;DR: In this paper, the first fullerene epoxide has been studied using calorimetry and high resolution powder X-ray diffraction, showing that at room temperature, C 60 O is orientationally disordered with a face-centered cubic lattice, a = 14.185 A. Upon cooling an orientational ordering transition at 278 K leads to a low temperature simple cubic phase.
Journal ArticleDOI
Design and synthesis of nonpeptide peptidomimetic inhibitors of renin
Amos B. Smith,Ryouichi Akaishi,David R. Jones,Terence P. Keenam,Mark C. Guzman,Ryan C. Holcomb,Paul A. Sprengeler,John L. Wood,Ralph Hirschmann,M. Katharine Holloway +9 more
TL;DR: Insight is provided into the role of hydrogen bonding and steric interactions for binding to renin and three of the four compounds gave IC50s in the 0.6 to 18 μM range.
Patent
Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
TL;DR: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodorolide are provided as discussed by the authors.