Thomas J. O'Shaughnessy

TL;DR: This is the first demonstration of CNS stem and progenitor cell-derived functional synapse and neuronal network formation in a 3D matrix, and the proliferative capacity and neuronal differentiating potential of neural progenitors in 3D collagen gels suggest their potential use in attempts to promote neuronal regeneration in vivo.

TL;DR: A portable system tailored to monitoring neuronal extracellular potentials that readily incorporates standardized microelectrode arrays developed by and in use at the University of North Texas is described.

TL;DR: It is demonstrated that an electric field typical of those found in neuronal membranes results in suppression of the QD photoluminescence (PL) and, for the first time, that QD PL is able to track the action potential profile of a firing neuron with millisecond time resolution.

TL;DR: In this paper, the cell-collagen-bioreactor culture system supports long-term NSC/NP growth and differentiation, and RWV bioreactors can be useful in generating neural tissue like constructs, which may have the potential for cell replacement therapy.

TL;DR: This is the first demonstration of functional synapse formation among neurons grown on 3D collagen gels, suggesting that type-I collagen can be a promising material for neuronal regeneration.