D
Dragan Maric
Researcher at National Institutes of Health
Publications - 213
Citations - 12150
Dragan Maric is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Neural stem cell. The author has an hindex of 54, co-authored 181 publications receiving 10189 citations. Previous affiliations of Dragan Maric include University of Medicine and Dentistry of New Jersey & United States Department of Health and Human Services.
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Journal ArticleDOI
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.
Benjamin Purow,Raqeeb M. Haque,Martha Noel,Qin Su,Michael J. Burdick,Jeongwu Lee,Tilak K. Sundaresan,Sandra Pastorino,John K. Park,Irina Mikolaenko,Dragan Maric,Charles G. Eberhart,Howard A. Fine +12 more
TL;DR: These results show, for the first time, the dependence of cancer cells on a single Notch ligand; they suggest a potential Notch juxtacrine/autocrine loop in gliomas and may present novel therapeutic targets in the treatment of glioma.
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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Kelly Jean Thomas,Melissa K. McCoy,Jeff Blackinton,Alexandra Beilina,Marcel P. van der Brug,Anna Sandebring,Anna Sandebring,David Miller,Dragan Maric,Angel Cedazo-Minguez,Mark R. Cookson +10 more
TL;DR: It is shown that loss of DJ-1 leads to loss of mitochondrial polarization, fragmentation of mitochondria and accumulation of markers of autophagy around mitochondria in human dopaminergic cells, and data suggest thatDJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment.
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Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Jeongwu Lee,Myung Jin Son,Kevin D. Woolard,Nicholas M. Donin,Aiguo Li,Chui H. Cheng,Svetlana Kotliarova,Yuri Kotliarov,Jennifer Walling,Susie Ahn,Misuk Kim,Mariam Totonchy,Thomas Cusack,Chibawanye I. Ene,Hilary Ma,Qin Su,Jean C. Zenklusen,Wei Zhang,Dragan Maric,Howard A. Fine +19 more
TL;DR: It is demonstrated that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs.
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Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast
Masaki Fukunaga,Tie-Qiang Li,Peter van Gelderen,Jacco A. de Zwart,Karin Shmueli,Bing Yao,Jongho Lee,Dragan Maric,Maria A. Aronova,Guofeng Zhang,Richard D. Leapman,John F. Schenck,Hellmut Merkle,Jeff H. Duyn +13 more
TL;DR: Iron is distributed over laminae in a pattern that is suggestive of each region’s myeloarchitecture and forms the dominant source of the observed MRI contrast.
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Human endogenous retrovirus-K contributes to motor neuron disease
Wenxue Li,Myoung Hwa Lee,Lisa J. Henderson,Richa Tyagi,Muzna Bachani,Joseph P. Steiner,Emilie Campanac,Dax A. Hoffman,Gloria von Geldern,Kory R. Johnson,Dragan Maric,H. Douglas Morris,Margaret R. Lentz,Katherine Pak,Andrew L. Mammen,Lyle W. Ostrow,Jeffrey D. Rothstein,Avindra Nath +17 more
TL;DR: It is shown that HERV-K is activated in a subpopulation of patients with sporadic amyotrophic lateral sclerosis (ALS) and that its envelope (env) protein may contribute to neurodegeneration and disease pathogenesis.