S
Susan M. Fischer
Researcher at University of Texas MD Anderson Cancer Center
Publications - 195
Citations - 9817
Susan M. Fischer is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Carcinogenesis & Tumor promotion. The author has an hindex of 55, co-authored 195 publications receiving 9442 citations. Previous affiliations of Susan M. Fischer include University of Tennessee & Oak Ridge National Laboratory.
Papers
More filters
Journal ArticleDOI
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
Susan M. Fischer,Herng-Hsang Lo,Gary Gordon,Karen Seibert,Gary J. Kelloff,Ronald A. Lubet,Claudio J. Conti +6 more
TL;DR: The dramatic protective effects of celecoxib suggests that specific COX‐2 inhibitors may offer a way to safely reduce the risk of skin cancer in humans.
Journal ArticleDOI
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
TL;DR: Although mezerein by itself is a weak promoter and mimics TPA in many biochemical and morphological effects it is a potent second-stage promoter in a two-stage promotion regimen, the results suggest that 4-O-methyl-TPA had weak activity as a first-stage promoters.
Journal ArticleDOI
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
Luis A. Garza,Yaping Liu,Zaixin Yang,Brinda Alagesan,John A. Lawson,Scott M. Norberg,Dorothy E. Loy,Tailun Zhao,Hanz Blatt,David C. Stanton,Lee Carrasco,Gurpreet Ahluwalia,Susan M. Fischer,Garret A. FitzGerald,George Cotsarelis +14 more
TL;DR: PGD2 is defined as an inhibitor of hair growth in AGA and the PGD2-GPR44 pathway is suggested as a potential target for treatment, providing new insight into the pathogenesis of AGA.
Journal ArticleDOI
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells
Imad Shureiqi,Wei Jiang,Xiangsheng Zuo,Yuanqing Wu,Julie B. Stimmel,Lisa M. Leesnitzer,Jeffrey S. Morris,Hui Zhen Fan,Susan M. Fischer,Scott M. Lippman +9 more
TL;DR: Findings indicate that the down-regulation of PPAR-δ by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs.
Journal ArticleDOI
Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells REGULATORY ROLE OF CCAAT/ENHANCER-BINDING PROTEINS IN THE DIFFERENTIAL EXPRESSION OF CYCLOOXYGENASE-2 IN NORMAL AND NEOPLASTIC TISSUES
Youngsoo Kim,Susan M. Fischer +1 more
TL;DR: Electrophoretic mobility shift assays and cotransfection experiments showed that upstream stimulatory factors and CCAAT/enhancer-binding proteins (C/EBPs) bind to the E-box and nuclear factor IL6 site, respectively, and functionally transactivate the COX-2 promoter, suggesting that overexpression of COX in tumors may be caused by a change in C/EBP expression levels.