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Thomas J. Weber
Researcher at Pacific Northwest National Laboratory
Publications - 39
Citations - 1161
Thomas J. Weber is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: MAPK/ERK pathway & Epidermal growth factor. The author has an hindex of 15, co-authored 39 publications receiving 1084 citations. Previous affiliations of Thomas J. Weber include Battelle Memorial Institute.
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Journal ArticleDOI
Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials
Debamitra Dutta,S. K. Sundaram,Justin G. Teeguarden,Brian J. Riley,Leonard S. Fifield,Jon M. Jacobs,Shane Raymond Addleman,George A. Kaysen,Brij M. Moudgil,Thomas J. Weber +9 more
TL;DR: Investigation of nanomaterial uptake or toxicity in the RAW 264.7 macrophage-like model suggests an important role for adsorbed proteins in modulating the uptake and toxicity of SWCNTs and nano-sized amorphous silica.
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In situ live cell sensing of multiple nucleotides exploiting DNA/RNA aptamers and graphene oxide nanosheets.
Ying Wang,Zhaohui Li,Zhaohui Li,Thomas J. Weber,Dehong Hu,Chiann Tso Lin,Jinghong Li,Yuehe Lin +7 more
TL;DR: The results demonstrate that the aptamers/GO-nS-based sensing platform is capable of selective, simultaneous, and in situ detection of multiple nucleotides, which hold a great potential for analyzing other biomolecules in living cells.
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AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model.
TL;DR: The findings suggest that the signaling pathway leading to the activation of ERK, TCF, and AP-1 proteins constitutes a major factor determining the risk of tumor promotion by TPA or EGF.
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Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data.
Katrina M. Waters,Tao Liu,Ryan D. Quesenberry,Alan Willse,Somnath Bandyopadhyay,Loel E. Kathmann,Thomas J. Weber,Richard D. Smith,H. Steven Wiley,Brian D. Thrall +9 more
TL;DR: The most robust response to mitogenic concentrations of EGF was induction of matrix metalloprotease cascades, highlighting the importance of the EGFR system as a regulator of the extracellular environment.
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A combined confocal and magnetic resonance microscope for biological studies
Paul D. Majors,Kevin R. Minard,Eric J. Ackerman,Gary R. Holtom,Derek F. Hopkins,Christopher I. Parkinson,Thomas J. Weber,Robert A. Wind +7 more
TL;DR: A novel microscope is described for studying live cells simultaneously with both confocal scanning laser fluorescence optical microscopy and magnetic resonance microscopy, and the layout and specifications of the instrument are given.