D
Derek F. Hopkins
Researcher at Pacific Northwest National Laboratory
Publications - 17
Citations - 398
Derek F. Hopkins is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Microscopy & Mass spectrometry. The author has an hindex of 7, co-authored 17 publications receiving 359 citations. Previous affiliations of Derek F. Hopkins include Environmental Molecular Sciences Laboratory.
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Journal ArticleDOI
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses.
Eric A. Livesay,Keqi Tang,Beverley K. Taylor,Michael A. Buschbach,Derek F. Hopkins,Brian L. LaMarche,Rui Zhao,Yufeng Shen,Daniel J. Orton,Ronald J. Moore,Ryan T. Kelly,Harold R. Udseth,Richard D. Smith +12 more
TL;DR: This system performs multiple LC separations in parallel, but staggers each of them such that the data-rich region of each separation is sampled sequentially, which maximizes the use of the mass spectrometer.
Journal ArticleDOI
An LC-IMS-MS platform providing increased dynamic range for high-throughput proteomic studies
Erin S. Baker,Eric A. Livesay,Daniel J. Orton,Ronald J. Moore,William F. Danielson,David C. Prior,Yehia M. Ibrahim,Brian L. LaMarche,Anoop Mayampurath,Athena A. Schepmoes,Derek F. Hopkins,Keqi Tang,Richard D. Smith,Mikhail E. Belov +13 more
TL;DR: The LC-IMS-TOF MS system enabled drift time separation of the low concentration spiked peptides from the high concentration mouse peptide matrix components, reducing signal interference and background, and allowing species to be resolved that would otherwise be obscured by other components.
Journal ArticleDOI
A method for determining the positions of polar hydrogens added to a protein structure that maximizes protein hydrogen bonding.
TL;DR: An automated method for the optimal placement of polar hydrogens in a protein structure is described, and the predictions from this method are compared to known hydrogen positions for bovine pancreatic trypsin inhibitor, insulin, RNase‐A, andtrypsin for which the neutron diffraction structures have been determined.
Journal ArticleDOI
A combined confocal and magnetic resonance microscope for biological studies
Paul D. Majors,Kevin R. Minard,Eric J. Ackerman,Gary R. Holtom,Derek F. Hopkins,Christopher I. Parkinson,Thomas J. Weber,Robert A. Wind +7 more
TL;DR: A novel microscope is described for studying live cells simultaneously with both confocal scanning laser fluorescence optical microscopy and magnetic resonance microscopy, and the layout and specifications of the instrument are given.
ReportDOI
Pulse Jet Mixing Tests With Noncohesive Solids
Perry A. Meyer,Judith Ann Bamberger,Carl W. Enderlin,James A. Fort,Beric E. Wells,S. K. Sundaram,Paul A. Scott,Michael J. Minette,Gary L. Smith,Carolyn A. Burns,Margaret S. Greenwood,Gerald P. Morgen,Ellen B. K. Baer,Sandra F. Snyder,Michael White,Gregory F. Piepel,Brett G. Amidan,Alejandro Heredia-Langner,Sharon A. Bailey,John C. Bower,Kayte M. Denslow,David E. Eakin,Monte R. Elmore,Phillip A. Gauglitz,Anthony D. Guzman,Brian K. Hatchell,Derek F. Hopkins,David E. Hurley,Michael D. Johnson,Leslie J. Kirihara,Bruce D. Lawler,Jesse S. Loveland,O Dennis Mullen,Mikhail Pekour,Timothy J. Peters,Peter J. Robinson,Michael S. Russcher,Susan Sande,Christian Santoso,Steven V. Shoemaker,Steve M. Silva,Devin E. Smith,Yin-Fong Su,James J. Toth,John D. Wiberg,Xiao-Ying Yu,Nino Zuljevic +46 more
TL;DR: In this paper, the authors present results from pulse jet mixing (PJM) tests with noncohesive solids in Newtonian liquid conducted during FY 2007 and 2008 to support the design of mixing systems for the Hanford Waste Treatment and Immobilization Plant (WTP).