T
Thomas K. Wolfgruber
Researcher at University of Hawaii
Publications - 17
Citations - 609
Thomas K. Wolfgruber is an academic researcher from University of Hawaii. The author has contributed to research in topics: Centromere & Software. The author has an hindex of 8, co-authored 17 publications receiving 528 citations. Previous affiliations of Thomas K. Wolfgruber include University of Hawaii at Manoa & University of Michigan.
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Journal ArticleDOI
Maize centromere structure and evolution: sequence analysis of centromeres 2 and 5 reveals dynamic Loci shaped primarily by retrotransposons.
Thomas K. Wolfgruber,Anupma Sharma,Kevin L. Schneider,Patrice S. Albert,Dal-Hoe Koo,Jinghua Shi,Zhi Gao,Fangpu Han,Hye-Ran Lee,Ronghui Xu,Jamie Allison,James A. Birchler,Jiming Jiang,R. Kelly Dawe,Gernot G. Presting +14 more
TL;DR: It is shown that maize centromeres are fluid genomic regions whose borders are heavily influenced by the interplay of retrotransposons and epigenetic marks, and it is proposed that CRMs may be involved in removal of centromeric DNA, invasion of centromere by non-CRM retro Transposons, and local repositioning of the CENH3.
Journal ArticleDOI
Tandem repeats derived from centromeric retrotransposons
TL;DR: Analysis of monomers from two different CRM1TR loci shows that gene conversion is the major cause of sequence variation, which supports the conclusions from earlier studies that retrotransposons can give rise to tandem repeats in eukaryotic genomes.
Journal ArticleDOI
Inbreeding drives maize centromere evolution.
TL;DR: Evidence strongly suggests that inbreeding, favored by postdomestication selection for centromere-linked genes affecting key domestication or agricultural traits, drives replacement of the tandem centromeres repeats in maize and other crop plants.
Journal ArticleDOI
Granatum: a graphical single-cell RNA-Seq analysis pipeline for genomics scientists.
Xun Zhu,Xun Zhu,Thomas K. Wolfgruber,Thomas K. Wolfgruber,Austin Tasato,Cedric Arisdakessian,Cedric Arisdakessian,David Garmire,Lana X. Garmire,Lana X. Garmire +9 more
TL;DR: Granatum enables broad adoption of scRNA-Seq technology by empowering bench scientists with an easy-to-use graphical interface for scRNAsq data analysis.
Journal ArticleDOI
Using single-cell multiple omics approaches to resolve tumor heterogeneity.
Michael A. Ortega,Olivier Poirion,Xun Zhu,Sijia Huang,Thomas K. Wolfgruber,Robert Sebra,Lana X. Garmire +6 more
TL;DR: Continuing advancements in single-cell technology and computational deconvolution of data will be critical for reconstructing patient specific intra-tumour features and developing more personalized cancer treatments.