T
Thomas M. Bartol
Researcher at Salk Institute for Biological Studies
Publications - 74
Citations - 3341
Thomas M. Bartol is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Dendritic spine & Voltage-dependent calcium channel. The author has an hindex of 27, co-authored 69 publications receiving 2848 citations. Previous affiliations of Thomas M. Bartol include University of California, San Diego & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Fast Monte Carlo Simulation Methods for Biological Reaction-Diffusion Systems in Solution and on Surfaces
Rex Kerr,Thomas M. Bartol,Boris Kaminsky,Markus Dittrich,Jen-Chien Jack Chang,Scott B. Baden,Terrence J. Sejnowski,Joel R. Stiles +7 more
TL;DR: It is shown how spatially realistic Monte Carlo simulations of biological systems can be far more cost-effective than often is assumed, and provide a level of accuracy and insight beyond that of continuum methods.
Journal ArticleDOI
Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle
TL;DR: It is concluded that passive transmitter diffusion, coupled with rapid expansion of the fusion pore, is sufficient to explain the time course of experimentally measured synaptic currents with trs of less than 100 micros.
Book ChapterDOI
Monte Carlo Methods for Simulating Realistic Synaptic Microphysiology Using MCell
Joel R. Stiles,Thomas M. Bartol +1 more
Journal ArticleDOI
Nanoconnectomic upper bound on the variability of synaptic plasticity
Thomas M. Bartol,Cailey Bromer,Justin P Kinney,Justin P Kinney,Michael A. Chirillo,Jennifer N. Bourne,Kristen M. Harris,Terrence J. Sejnowski,Terrence J. Sejnowski +8 more
TL;DR: In an EM reconstruction of hippocampal neuropil, single axons are found making two or more synaptic contacts onto the same dendrites, having shared histories of presynaptic and postsynaptic activity.
Journal ArticleDOI
Evidence for ectopic neurotransmission at a neuronal synapse.
Jay S. Coggan,Jay S. Coggan,Thomas M. Bartol,Thomas M. Bartol,Eduardo Esquenazi,Joel R. Stiles,Joel R. Stiles,Stephan Lamont,Maryann E. Martone,Darwin K. Berg,Mark H. Ellisman,Terrence J. Sejnowski +11 more
TL;DR: Simulated synaptic activity is consistent with experimental recordings of miniature excitatory postsynaptic currents only when ectopic transmission is included in the model, broadening the possibilities for mechanisms of neuronal communication.