T
Thomas Müller
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 40
Citations - 3744
Thomas Müller is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Artificial pancreas & Diabetes mellitus. The author has an hindex of 28, co-authored 40 publications receiving 3513 citations. Previous affiliations of Thomas Müller include W. R. Grace and Company.
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Journal ArticleDOI
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System
Bastian G. Brinkmann,Amit Agarwal,Michael W. Sereda,Michael W. Sereda,Alistair N. Garratt,Thomas Müller,Hagen Wende,Ruth M. Stassart,Schanila Nawaz,Christian Humml,Viktorija Velanac,Konstantin Radyushkin,Sandra Goebbels,Tobias M. Fischer,Robin J.M. Franklin,Cary Lai,Hannelore Ehrenreich,Carmen Birchmeier,Markus H. Schwab,Klaus-Armin Nave +19 more
TL;DR: NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ ErbB-independent mechanism of myelination control, and is tested by generating a series of conditional null mutants that completely lack NRG1 beginning at different stages of neural development.
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The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
TL;DR: The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabolism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development.
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Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo
Martin M. Sachs,Henning Brohmann,Dietmar Zechner,Thomas Müller,Jörg Hülsken,Ingrid Walther,Ute Schaeper,Carmen Birchmeier,Walter Birchmeier +8 more
TL;DR: The functional analysis of Gab1 by targeted mutagenesis in the mouse is reported, and extensive similarities between the phenotypes of c-Met and HGF/SF mutant mice exist, and the muscle migration phenotype is even more pronounced in Gab1−/−:c-Met+/− embryos, genetic evidence that Gab1 is essential for c- Met signaling in vivo.
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Biohybrid artificial pancreas: long-term implantation studies in diabetic, pancreatectomized dogs
Susan J. Sullivan,Takashi Maki,Kermit M. Borland,Michele D. Mahoney,Barry A. Solomon,Thomas Müller,Anthony P. Monaco,William L. Chick +7 more
TL;DR: The biohybrid perfused artificial pancreas was designed to incorporate islet tissue and a selectively permeable membrane that isolates this tissue from the immune system of the recipient.
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Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine.
TL;DR: The phenotype of crest‐derived cells was examined as they differentiated into neurons or glia in the mouse small and large intestine and expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type–specific markers.