T
Thomas Philipp Hoernes
Researcher at Innsbruck Medical University
Publications - 9
Citations - 296
Thomas Philipp Hoernes is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: RNA & Messenger RNA. The author has an hindex of 6, co-authored 8 publications receiving 198 citations.
Papers
More filters
Journal ArticleDOI
Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
Thomas Philipp Hoernes,Nina Clementi,Klaus Faserl,Heidelinde Glasner,Kathrin Breuker,Herbert Lindner,Alexander Hüttenhofer,Matthias D. Erlacher +7 more
TL;DR: The results suggest a novel mode of gene regulation by nucleotide modifications in bacterial mRNAs, which is consistent with stalling of translation at the modified codon of the bacterial ErmCL mRNA.
Journal ArticleDOI
mRNA modifications: Dynamic regulators of gene expression?
TL;DR: Results implicate that mRNA modifications are a powerful mechanism to post-transcriptionally regulate gene expression.
Journal ArticleDOI
Translating the epitranscriptome
TL;DR: Some recent findings on various co‐ and post‐transcriptional modifications of messenger RNA are summarized and highlighted, describing the impact of these processes on gene expression, with emphasis on protein synthesis.
Journal ArticleDOI
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
Thomas Philipp Hoernes,Klaus Faserl,Michael Andreas Juen,Johannes Kremser,Catherina Gasser,Elisabeth Fuchs,Xinying Shi,Aaron Siewert,Herbert Lindner,Christoph Kreutz,Ronald Micura,Simpson Joseph,Claudia Höbartner,Eric Westhof,Alexander Hüttenhofer,Matthias D. Erlacher +15 more
TL;DR: Non-standard nucleotides in bacterial and eukaryotic mRNA are introduced to reveal the minimal hydrogen bond requirement of codon-anticodon interaction for efficient and accurate translation.
Journal ArticleDOI
Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs.
Thomas Philipp Hoernes,David Heimdörfer,Daniel Köstner,Klaus Faserl,Felix Nußbaumer,Raphael Plangger,Christoph Kreutz,Herbert Lindner,Matthias D. Erlacher +8 more
TL;DR: The analysis of the respective protein products revealed a strong position-dependent impact of RNA modifications on translation efficiency and accuracy, and the set of mRNA modifications tested in HEK293T cells could not be attributed to any miscoding potential.