T
Thomas Pietschmann
Researcher at University of Mainz
Publications - 4
Citations - 1013
Thomas Pietschmann is an academic researcher from University of Mainz. The author has contributed to research in topics: RNA & NS2-3 protease. The author has an hindex of 3, co-authored 4 publications receiving 1006 citations.
Papers
More filters
Journal ArticleDOI
Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture
Thomas Pietschmann,Volker Lohmann,Artur Kaul,Nicole Krieger,Gabriele Rinck,Gabriel Rutter,Dennis Strand,Ralf Bartenschlager +7 more
TL;DR: It is suggested that Huh-7 cells lack host cell factors that are important for virus particle assembly and/or release, and selectable full-length HCV genomes that amplify to high levels in the human hepatoma cell line Huh- 7 are generated.
Journal ArticleDOI
Characterization of Cell Lines Carrying Self-Replicating Hepatitis C Virus RNAs
TL;DR: High levels of HCV RNAs were preserved in cells passaged under continuous selection, and depending on culture conditions the RNAs persisted for more than 10 months, suggesting that cellular factors required for RNA replication and/or translation vary in abundance and become limiting in resting cells.
Journal ArticleDOI
Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway
TL;DR: It is shown here that IFN-α inhibits subgenomic HCV RNA replication in HuH-7 human hepatoma cells in a dose-dependent manner and whether MxA plays a role in the inhibition of HCV is investigated.
Patent
Utilisation d'inhibiteurs de phospholipase a2 pour traiter ou prévenir une infection à flavivirus
TL;DR: The authors concerne des inhibiteurs de phospholipase A 2 (egalement appelee PLA2) destines a etre utilises pour traiter ou prevenir une infection a Flavivirus, en particulier, une infection par un Flaviverirus du genre Flavi ou du genre Hepaci.