T
Thomas Shiovitz
Publications - 4
Citations - 503
Thomas Shiovitz is an academic researcher. The author has contributed to research in topics: Tolerability & Randomized controlled trial. The author has an hindex of 3, co-authored 4 publications receiving 430 citations.
Papers
More filters
Journal ArticleDOI
Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
Vladimir Coric,Christopher H. van Dyck,Stephen Salloway,Niels Andreasen,Mark Brody,Ralph W. Richter,Hilkka Soininen,Stephen G. Thein,Thomas Shiovitz,Gary Pilcher,Susan Colby,Linda Rollin,Randy C. Dockens,Chahin Pachai,Erik Portelius,Ulf Andreasson,Kaj Blennow,Holly Soares,Charles F. Albright,Howard Feldman,Robert M. Berman +20 more
TL;DR: This study establishes an acceptable safety and tolerability dose range for future avagacestat studies in AD and provides preliminary support for -secretase target engagement in patients with mild to moderate Alzheimer disease.
Journal ArticleDOI
Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial
Vladimir Coric,Stephen Salloway,Christopher H. van Dyck,Bruno Dubois,Niels Andreasen,Mark Brody,Craig Curtis,Hilkka Soininen,Stephen G. Thein,Thomas Shiovitz,Gary Pilcher,Steven H. Ferris,Susan Colby,Wendy Kerselaers,Randy C. Dockens,Holly Soares,Stephen Kaplita,Feng Luo,Chahin Pachai,Luc Bracoud,Mark A. Mintun,Joshua D. Grill,Ken Marek,John Seibyl,Jesse M. Cedarbaum,Charles F. Albright,Howard Feldman,Robert M. Berman +27 more
TL;DR: Avagacestat did not demonstrate efficacy and was associated with adverse dose-limiting effects in this PDAD population, which had higher rates of clinical progression to dementia and greater brain atrophy compared with CSF biomarker-negative participants.
Journal ArticleDOI
Safety and tolerability of BMS-708163 in a phase II study in mild-to-moderate Alzheimer's disease
Stephen Salloway,Vlad Coric,Mark Brody,Niels Andreasen,Christopher H. van Dyck,Hilkka Soininen,Stephen G. Thein,Thomas Shiovitz,Sandeep Kumar,Gary Pilcher,Susan Colby,Linda Rollin,Howard Feldman,Robert M. Berman +13 more
Journal ArticleDOI
Volumetric mri results of bms avagacestat in a prodromal ad population
Audrey Istace,Luc Bracoud,Robert M. Berman,Feng Luo,Florent Roche,Stephen Salloway,Christopher H. van Dyck,Bruno Dubois,Niels Andreasen,Mark Brody,Craig Curtis,Hilkka Soininen,Stephen G. Thein,Thomas Shiovitz,Steven H. Ferris,Joshua D. Grill,Sylvain Gouttard,Joël Schaerer,Wendy Hayes,Stephen Kaplita,Boubakeur Belaroussi,Hui Jing Yu,Jesse M. Cedarbaum,Howard Feldman,Chahin Pachai,Vlad Coric +25 more