H
Holly Soares
Researcher at Pfizer
Publications - 60
Citations - 7472
Holly Soares is an academic researcher from Pfizer. The author has contributed to research in topics: Alzheimer's disease & Alzheimer's Disease Neuroimaging Initiative. The author has an hindex of 28, co-authored 57 publications receiving 6612 citations. Previous affiliations of Holly Soares include Bristol-Myers Squibb.
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Journal ArticleDOI
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Leslie M. Shaw,Hugo Vanderstichele,Malgorzata Knapik-Czajka,Christopher M. Clark,Paul S. Aisen,Ronald C. Petersen,Kaj Blennow,Holly Soares,Adam J. Simon,Piotr Lewczuk,Robert A. Dean,Eric Siemers,William Z. Potter,Virginia M.-Y. Lee,John Q. Trojanowski +14 more
TL;DR: Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects.
Journal ArticleDOI
The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans
Michael W. Weiner,Michael W. Weiner,Paul S. Aisen,Clifford R. Jack,William J. Jagust,John Q. Trojanowski,Leslie M. Shaw,Andrew J. Saykin,John C. Morris,Nigel J. Cairns,Laurel A. Beckett,Arthur W. Toga,Robert C. Green,Sarah Walter,Holly Soares,Peter J. Snyder,Eric Siemers,William Z. Potter,Patricia E. Cole,Mark E. Schmidt +19 more
TL;DR: Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects, and ADNI provides significant new information concerning the progression of AD.
Journal ArticleDOI
Plasma Aβ1–40 and Aβ1–42 and the risk of dementia: a prospective case-cohort study
TL;DR: A potential role of plasma Aβ concentrations as a marker of incipient dementia warrants further investigation, and associations were similar for Alzheimer's disease and vascular dementia.
Journal ArticleDOI
Current state of Alzheimer's fluid biomarkers.
José Luis Molinuevo,Scott Ayton,Richard Batrla,Martin M. Bednar,Tobias Bittner,Jeffrey L. Cummings,Anne M. Fagan,Harald Hampel,Michelle M. Mielke,Alvydas Mikulskis,Sid E. O'Bryant,Philip Scheltens,Jeffrey Sevigny,Leslie M. Shaw,Holly Soares,Gary Tong,John Q. Trojanowski,Henrik Zetterberg,Kaj Blennow +18 more
TL;DR: Some of the pathological mechanisms implicated in the sporadic AD are summarized and the data for several established and novel fluid biomarkers associated with each mechanism are highlighted.
Journal ArticleDOI
CSF biomarker variability in the Alzheimer's Association quality control program
Niklas Mattsson,Niklas Mattsson,Ulf Andreasson,Staffan Persson,Maria C. Carrillo,Steven J. Collins,Sonia Chalbot,Neal Cutler,Diane Dufour-Rainfray,Anne M. Fagan,Niels H. H. Heegaard,Ging-Yuek Robin Hsiung,Bradley T. Hyman,Khalid Iqbal,D. Richard Lachno,Alberto Lleó,Piotr Lewczuk,José Luis Molinuevo,Piero Parchi,Axel Regeniter,Robert A. Rissman,Hanna Rosenmann,Giuseppe Sancesario,Johannes Schröder,Leslie M. Shaw,Charlotte E. Teunissen,John Q. Trojanowski,Hugo Vanderstichele,Manu Vandijck,Marcel M. Verbeek,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Stephan A. Käser,Aladro José A. Rojo,Marilyn S. Albert,Daniel Alcolea,Anna Antonell,Hiroyuki Arai,Silvana Archetti,Eva Arkblad,Inês Baldeiras,Ales Bartos,Dev Batish,Aurélie Bedel,Daniele Bentue-Ferrer,Flora Berisha,Sergio Bernardini,Marinus A. Blankenstein,Olivier Bousiges,Michael C. Camuso,Maria Berrocal Carrillo,Tiziana Casoli,Sebastiano Cavallaro,Odete A. da Cruz e Silva,Isabelle Cuvelier,Odile Delaroche,Roy B. Dyer,Sebastiaan Engelborghs,Anne Fogli,Orestes Vicente Forlenza,Nick C. Fox,Giovanni B. Frisoni,Daniela Galimberti,Elisabetta Galloni,Silvana Gritti,Karen H. Gylys,Harald Hampel,Sabine Haustein,Theresa Heath,Michael T. Heneka,Sanna-Kaisa Herukka,David M. Holtzman,Christian Humpel,Takeshi Iwatsubo,Claude Jardel,Mathias Jucker,Elisabeth Kapaki,Daniel Kidd,Péter Klivényi,Ryozo Kuwano,Foudil Lamari,Jean-Louis Laplanche,Jordan Laser,Sylvian Lehmann,Qiao-Xin Li,Walter Maetzler,Catherine Malaplate-Armand,Ralph Martin,Robert Martone,Colin L. Masters,Marc Mercken,Jose Luis Molinuevo,T. J. Montine,William Nowatzke,Markus Otto,Xavier Parent,Lucilla Parnetti,Ronald C. Petersen,Koen Poesen,Isabelle Quadrio,Muriel Quillard,Vara Luis Rello,Zdenek Rohan,Christin Sisowath,Anders Skinningsrud,Holly Soares,Hilkka Soininen,Knudsen Cindy Søndersø,Annette Spreer,Silvia Suardi,C.E. Teunissen,Robert M. Umek,Bianca Van Broeck,Rik Vandenberghe,László Vécsei,M.M. Verbeek,Igor Vostiar,Manfred Windisch +118 more
TL;DR: The cerebrospinal fluid biomarkers amyloid beta 1–42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease research and patient management, but there are large variations in biomarker measurements among and within laboratories.