T
Thomas Trian
Researcher at French Institute of Health and Medical Research
Publications - 32
Citations - 722
Thomas Trian is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 13, co-authored 22 publications receiving 582 citations. Previous affiliations of Thomas Trian include Université Bordeaux Segalen & Woolcock Institute of Medical Research.
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Journal ArticleDOI
The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology
Annaig Ozier,Benoit Allard,Imane Bara,Pierre-Olivier Girodet,Thomas Trian,Roger Marthan,Patrick Berger +6 more
TL;DR: The pivotal role of airway smooth muscle (ASM) in the pathophysiology of asthma is reviewed to review the mechanisms of AHR in asthma and how ASM remodelling represents a key feature of asthmatic bronchial remodelling.
Journal ArticleDOI
Phenotype modulation of airway smooth muscle in asthma.
David Wright,Thomas Trian,Sana Siddiqui,Sana Siddiqui,Christopher D. Pascoe,Jill R. Johnson,Bart G. J. Dekkers,Shyamala Dakshinamurti,Rushita A. Bagchi,Janette K. Burgess,Varsha Kanabar,Oluwaseun O. Ojo +11 more
TL;DR: There is overwhelming evidence suggesting that the immunomodulatory response of ASM is due to the acquisition of a synthetic phenotype; however, whether this degree of plasticity is present in vivo as opposed to cell culture-based models remains speculative.
Journal ArticleDOI
β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
Thomas Trian,Janette K. Burgess,Kyoko Niimi,Kyoko Niimi,Lyn M. Moir,Lyn M. Moir,Qi Ge,Qi Ge,Patrick Berger,Stephen B. Liggett,Judith L. Black,Judith L. Black,Brian G. Oliver,Brian G. Oliver +13 more
TL;DR: Low cAMP production in asthmatic ASM from asthmatics results from enhanced degradation due to increased PDE4D expression, and clinical manifestations of this dysregulation would be suboptimal β-agonist-mediated bronchodilation and possibly reduced control over increasing ASM mass.
Journal ArticleDOI
Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study
Pierre-Olivier Girodet,Gaël Dournes,Matthieu Thumerel,Hugues Begueret,Pierre Dos Santos,Annaig Ozier,Isabelle Dupin,Thomas Trian,Michel Montaudon,François Laurent,Roger Marthan,Patrick Berger +11 more
TL;DR: Gallopamil treatment for 12 months reduces BSM remodeling and prevents the occurrence of asthma exacerbations.
Journal ArticleDOI
House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.
Thomas Trian,Benoit Allard,Isabelle Dupin,Gabrielle Carvalho,Olga Ousova,Elise Maurat,Jehan Bataille,Matthieu Thumerel,Hugues Begueret,Pierre-Olivier Girodet,Roger Marthan,Patrick Berger +11 more
TL;DR: It was found that epithelial stimulation by HDM selectively increased the proliferation of asthmatic BSM cells and not that of nonasthmatic cells, demonstrating the selective role of HDM on BSM remodeling in patients with severe asthma.