Thorsten Steinberg

TL;DR: The first red/far-red light-triggered gene switch for mammalian cells for achieving gene expression control in time and space is described and it is shown that the system can reversibly be toggled between stable on- and off-states using short light pulses at 660 or 740 nm.

TL;DR: This work demonstrates for the first time multi-chromatic expression control in mammalian cells by differentially inducing up to three genes in a single cell culture in response to light of different wavelengths.

TL;DR: It is shown that mechanical strain modulates the amount of the matrix metalloproteinase MMP-13, and induces non-coherent modulation in the amount and activity of signal transducing molecules, such as FAK, MAP-kinases p42/44, and p38 stress kinase, suggesting their mechanistic role in mechano-transduction.

TL;DR: The key role of focal-adhesion kinase (FAK) in mechanobiology is discussed, since it is involved in mediating the transformation of environmental biomechanical signals into cell behavioural responses via mechanotransducing signalling cascades.

TL;DR: The results revealed specific problems that may occur when testing the antimicrobial activity of amphiphilic cationic polymers, and confirmed the working hypothesis that the more hydrophilic SMAMP polymers in the portfolio were ‘doubly selective’, i.e. selective for bacteria over mammalian cells, but also for Gram-positive over Gram-negative bacteria.