Jens Timmer

TL;DR: This work suggests an approach that exploits the profile likelihood that enables to detect structural non-identifiabilities, which manifest in functionally related model parameters, that might arise due to limited amount and quality of experimental data.

TL;DR: This work identifies WNT and its inhibitor DKK as primary determinants of murine hair follicle spacing, using a combined experimental and computational modeling approach and provides in vivo corroboration of the reaction-diffusion mechanism for epidermal appendage formation.

TL;DR: A mathematical model of the core module of the Janus family of kinases (JAK)–signal transducer and activator of transcription (STAT) signaling pathway based on time-resolved measurements of receptor and STAT5 phosphorylation reveals that STAT5 undergoes rapid nucleocytoplasmic cycles, continuously coupling receptor activation and target gene transcription, thereby forming a remote sensor between nucleus and receptor.

TL;DR: The expression dynamics of KLU suggest a model of how the arrest of cell proliferation is coupled to the attainment of a certain primordium size, implying a common principle of size measurement in plants and animals.

TL;DR: The results suggest that this pathway has evolved to show an optimal chemotactic performance while minimizing the cost of resources associated with high levels of protein expression, and the underlying topological design principles compensating for intercellular variations seem to be highly conserved among bacterial chemosensory systems.